Detection and diagnosis of herpes simplex virus infection in adults with acute liver failure
dc.contributor.author | Levitsky, Josh | en_US |
dc.contributor.author | Duddempudi, Anupama T. | en_US |
dc.contributor.author | Lakeman, Fred D. | en_US |
dc.contributor.author | Whitley, Richard J. | en_US |
dc.contributor.author | Luby, James P. | en_US |
dc.contributor.author | Lee, William M. | en_US |
dc.contributor.author | Fontana, Robert John | en_US |
dc.contributor.author | Blei, Andres T. | en_US |
dc.contributor.author | Ison, Michael G. | en_US |
dc.date.accessioned | 2008-11-03T18:53:24Z | |
dc.date.available | 2009-11-06T18:12:56Z | en_US |
dc.date.issued | 2008-10 | en_US |
dc.identifier.citation | Levitsky, Josh; Duddempudi, Anupama T.; Lakeman, Fred D.; Whitley, Richard J.; Luby, James P.; Lee, William M.; Fontana, Robert J.; Blei, Andres T.; Ison, Michael G. (2008). "Detection and diagnosis of herpes simplex virus infection in adults with acute liver failure." Liver Transplantation 14(10): 1498-1504. <http://hdl.handle.net/2027.42/61222> | en_US |
dc.identifier.issn | 1527-6465 | en_US |
dc.identifier.issn | 1527-6473 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/61222 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=18825709&dopt=citation | en_US |
dc.description.abstract | Disseminated herpes simplex virus (HSV) infection may lead to acute liver failure (ALF) and the need for emergency liver transplantation (LT). The primary aim of this study was to determine the utility of HSV serological testing and HSV DNA testing by polymerase chain reaction (PCR) in the diagnosis and management of indeterminate, pregnancy-related, and known HSV-related ALF. Stored sera obtained on study day 1 or 2 from patients enrolled in the United States ALF Study Group with indeterminate (n = 51), pregnancy-related (n = 12), and HSV-related (n = 4) ALF were screened for HSV DNA by PCR and serology. While 7 of the indeterminate and pregnant patients had positive anti-HSV immunoglobulin M, none had detectable HSV DNA. The 4 known HSV cases all had high-titer HSV DNA on presentation (range: 3.5 to 36 × 10 8 copies/mL). Two HSV patients underwent LT but developed posttransplant extrahepatic HSV infection despite suppression of HSV DNA with acyclovir treatment, and one of them eventually died. The 2 other fulminant HSV patients died within 48 hours of presentation. In conclusion, serum HSV DNA indicative of occult HSV infection was not detected in 51 indeterminate and 12 pregnancy-related ALF patients. The 4 patients with known HSV-related ALF all had high HSV DNA levels at presentation, and despite the rapid use of antiviral therapy and emergency LT, substantial morbidity and mortality were encountered, highlighting the poor prognosis with severe disseminated HSV infection. Liver Transpl 14:1498–1504, 2008. © 2008 AASLD. | en_US |
dc.format.extent | 151690 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Surgery | en_US |
dc.title | Detection and diagnosis of herpes simplex virus infection in adults with acute liver failure | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Surgery and Anesthesiology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | University of Michigan Health System, Ann Arbor, MI | en_US |
dc.contributor.affiliationother | Northwestern Memorial Hospital/Northwestern University Feinberg School of Medicine, Chicago, IL ; Telephone: 312-695-4413; FAX: 312-695-0036 ; Division of Hepatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Northwestern Memorial Hospital, 675 North St. Clair Street, Suite 15-250, Chicago, IL 60611 | en_US |
dc.contributor.affiliationother | University of Texas Southwestern Medical Center, Dallas, TX | en_US |
dc.contributor.affiliationother | University of Alabama at Birmingham Health System, Birmingham, AL | en_US |
dc.contributor.affiliationother | University of Alabama at Birmingham Health System, Birmingham, AL | en_US |
dc.contributor.affiliationother | University of Texas Southwestern Medical Center, Dallas, TX | en_US |
dc.contributor.affiliationother | University of Texas Southwestern Medical Center, Dallas, TX | en_US |
dc.contributor.affiliationother | Northwestern Memorial Hospital/Northwestern University Feinberg School of Medicine, Chicago, IL | en_US |
dc.contributor.affiliationother | Northwestern Memorial Hospital/Northwestern University Feinberg School of Medicine, Chicago, IL | en_US |
dc.identifier.pmid | 18825709 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/61222/1/21567_ftp.pdf | |
dc.identifier.doi | http://dx.doi.org/10.1002/lt.21567 | en_US |
dc.identifier.source | Liver Transplantation | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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