Pitx2 deletion in pituitary gonadotropes is compatible with gonadal development, puberty, and fertility
dc.contributor.author | Charles, Michael A. | en_US |
dc.contributor.author | Mortensen, Amanda H. | en_US |
dc.contributor.author | Potok, Mary Anne | en_US |
dc.contributor.author | Camper, Sally A. | en_US |
dc.date.accessioned | 2008-11-03T18:54:20Z | |
dc.date.available | 2009-11-06T18:12:56Z | en_US |
dc.date.issued | 2008-10 | en_US |
dc.identifier.citation | Charles, Michael A.; Mortensen, Amanda H.; Potok, Mary Anne; Camper, Sally A. (2008). " Pitx2 deletion in pituitary gonadotropes is compatible with gonadal development, puberty, and fertility." genesis 46(10): 507-514. <http://hdl.handle.net/2027.42/61237> | en_US |
dc.identifier.issn | 1526-954X | en_US |
dc.identifier.issn | 1526-968X | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/61237 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=18802953&dopt=citation | en_US |
dc.description.abstract | This report introduces a gonadotrope-specific cre transgenic mouse capable of ablating floxed genes in mature pituitary gonadotropes. Initial analysis of this transgenic line, Tg(Lhb-cre)1Sac , reveals that expression is limited to the pituitary cells that produce luteinizing hormone beta, beginning appropriately at e17.5. Cre activity is detectable by a reporter gene in nearly every LHΒ-producing cell, but the remaining hormone-producing cell types and other organs exhibit little to no activity. We used the Tg(Lhb-cre)1Sac strain to assess the role Pitx2 in gonadotrope function. The gonadotrope-specific Pitx2 knockout mice exhibit normal expression of LHΒ, sexual maturation, and fertility, suggesting that Pitx2 is not required for gonadotrope maintenance or for regulated production of gonadotropins. genesis 46:507–514, 2008. © 2008 Wiley-Liss, Inc. | en_US |
dc.format.extent | 1662029 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Genetics | en_US |
dc.title | Pitx2 deletion in pituitary gonadotropes is compatible with gonadal development, puberty, and fertility | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Genetics | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Human Genetics, University of Michigan, Ann Arbor, Michigan ; Michael A. Charles, Amanda H. Mortensen, and Mary Anne Potok contributed equally to this work. | en_US |
dc.contributor.affiliationum | Department of Human Genetics, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Human Genetics, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Human Genetics, University of Michigan, Ann Arbor, Michigan ; Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109-0618 | en_US |
dc.identifier.pmid | 18802953 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/61237/1/20398_ftp.pdf | |
dc.identifier.doi | http://dx.doi.org/10.1002/dvg.20398 | en_US |
dc.identifier.source | genesis | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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