Optical nanoparticle sensors for quantitative intracellular imaging
dc.contributor.author | Lee, Yong-Eun Koo | en_US |
dc.contributor.author | Kopelman, Raoul | en_US |
dc.date.accessioned | 2008-12-01T20:59:19Z | |
dc.date.available | 2010-02-02T15:48:06Z | en_US |
dc.date.issued | 2009-01 | en_US |
dc.identifier.citation | Lee, Yong-Eun Koo; Kopelman, Raoul (2009). "Optical nanoparticle sensors for quantitative intracellular imaging." Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology 1(1): 98-110. <http://hdl.handle.net/2027.42/61310> | en_US |
dc.identifier.issn | 1939-5116 | en_US |
dc.identifier.issn | 1939-0041 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/61310 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=20049782&dopt=citation | en_US |
dc.description.abstract | Real-time measurements of biological/chemical/physical processes, with no interferences, are an ultimate goal for in vivo intracellular studies. To construct intracellular biosensors that meet such a goal, nanoparticle (NP) platforms seem to be most promising, because of their small size and excellent engineerability. This review describes the development of NP-based opical sensors and their intracellular applications. The sensor designs are classified into two types, based on the sensor structures regarding analyte receptor and signal transducer. Type 1 sensors, with a single component for both receptor and transducer, work by mechanisms similar to those of ‘molecular probes’. Type 2 sensors, with a separate component for receptor and transducer, work by different mechanisms that require the presence of specific NPs. A synergistic increase in optical signal or selectivity has been reported for these second type of NP sensors. With ongoing rapid advances in nanotechnology and instrumentation, these NP systems will soon be capable of sensing at the single-molecule level, at the point of interest within the living cell, and capable of simultaneously detecting multiple analytes and physical parameters. Copyright © 2008 John Wiley & Sons, Inc. | en_US |
dc.format.extent | 805758 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Medicine | en_US |
dc.subject.other | Nanotechnology & Nanomaterials | en_US |
dc.title | Optical nanoparticle sensors for quantitative intracellular imaging | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Biomedical Engineering | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | University of Michigan, Ann Arbor, MI, USA ; University of Michigan, Ann Arbor, MI, USA. | en_US |
dc.contributor.affiliationum | University of Michigan, Ann Arbor, MI, USA ; University of Michigan, Ann Arbor, MI, USA. | en_US |
dc.identifier.pmid | 20049782 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/61310/1/2_ftp.pdf | |
dc.identifier.doi | http://dx.doi.org/10.1002/wnan.2 | en_US |
dc.identifier.source | Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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