Liver transplantation and subsequent risk of cancer: Findings from a Canadian cohort study See Editorial on Page 1561
dc.contributor.author | Jiang, Ying | en_US |
dc.contributor.author | Villeneuve, Paul J. | en_US |
dc.contributor.author | Fenton, Stanley S. A. | en_US |
dc.contributor.author | Schaubel, Douglas E. | en_US |
dc.contributor.author | Lilly, Les | en_US |
dc.contributor.author | Mao, Yang | en_US |
dc.date.accessioned | 2008-12-01T20:59:46Z | |
dc.date.available | 2010-01-05T16:59:13Z | en_US |
dc.date.issued | 2008-11 | en_US |
dc.identifier.citation | Jiang, Ying; Villeneuve, Paul J.; Fenton, Stanley S. A.; Schaubel, Douglas E.; Lilly, Les; Mao, Yang (2008). "Liver transplantation and subsequent risk of cancer: Findings from a Canadian cohort study See Editorial on Page 1561 ." Liver Transplantation 14(11): 1588-1597. <http://hdl.handle.net/2027.42/61315> | en_US |
dc.identifier.issn | 1527-6465 | en_US |
dc.identifier.issn | 1527-6473 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/61315 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=18975293&dopt=citation | en_US |
dc.description.abstract | Characterization of the long-term cancer risks among liver transplant patients has been hampered by the paucity of sufficiently large cohorts. The increase over time in the number of liver transplants coupled with improved survival underscores the need to better understand associated long-term health effects. This is a cohort study whose subjects were assembled with data from the population-based Canadian Organ Replacement Registry. Analyses are based on 2034 patients who received a liver transplant between June 1983 and October 1998. Incident cases of cancer were identified through record linkage to the Canadian Cancer Registry. We compared site-specific cancer incidence rates in the cohort and the general Canadian population by using the standardized incidence ratio (SIR). Stratified analyses were performed to examine variations in risk according to age at transplantation, sex, time since transplantation, and year of transplantation. Liver transplant recipients had cancer incidence rates that were 2.5 times higher than those of the general population [95% confidence interval (CI) = 2.1, 3.0]. The highest SIR was observed for non-Hodgkin's lymphoma (SIR = 20.8, 95% CI = 14.9, 28.3), whereas a statistically significant excess was observed for colorectal cancer (SIR = 2.6, 95% CI = 1.4, 4.4). Risks were more pronounced during the first year of follow-up and among younger transplant patients. In conclusion, our findings indicate that liver transplant patients face increased risks of developing cancer with respect to the general population. Increased surveillance in this patient population, particularly in the first year following transplantation, and screening for colorectal cancer with modalities for which benefits are already well recognized should be pursued. Liver Transpl 14:1588–1597, 2008. © 2008 AASLD. | en_US |
dc.format.extent | 150745 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Surgery | en_US |
dc.title | Liver transplantation and subsequent risk of cancer: Findings from a Canadian cohort study See Editorial on Page 1561 | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Surgery and Anesthesiology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Biostatistics, University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationother | Centre for Chronic Disease Prevention and Control, Public Health Agency of Canada, Ottawa, Ontario, Canada | en_US |
dc.contributor.affiliationother | Department of Public Health Sciences, University of Toronto, Toronto, Ontario, Canada | en_US |
dc.contributor.affiliationother | Division of Nephrology, Toronto General Hospital, Toronto, Ontario, Canada | en_US |
dc.contributor.affiliationother | Gastroenterology and Hepatology Transplant Unit, Toronto General Hospital, Toronto, Ontario, Canada | en_US |
dc.contributor.affiliationother | Centre for Chronic Disease Prevention and Control, Public Health Agency of Canada, Ottawa, Ontario, Canada ; Telephone: 613-957-1765; FAX: 613-941-2633 ; Centre for Chronic Disease Prevention and Control, Public Health Agency of Canada, 785 Carling Avenue, Ottawa, Ontario, Canada K1A 0K9 | en_US |
dc.identifier.pmid | 18975293 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/61315/1/21554_ftp.pdf | |
dc.identifier.doi | http://dx.doi.org/10.1002/lt.21554 | en_US |
dc.identifier.source | Liver Transplantation | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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