Medicinal Organometallic Chemistry: Designing Metal Arene Complexes as Anticancer Agents
dc.contributor.author | Peacock, Anna F. A. | en_US |
dc.contributor.author | Sadler, Peter J. | en_US |
dc.date.accessioned | 2008-12-01T21:01:35Z | |
dc.date.available | 2010-01-05T16:59:14Z | en_US |
dc.date.issued | 2008-11-13 | en_US |
dc.identifier.citation | Peacock, Anna 14F. 14A.; Sadler, Peter 14J. (2008). "Medicinal Organometallic Chemistry: Designing Metal Arene Complexes as Anticancer Agents." Chemistry - An Asian Journal 3(11): 1890-1899. <http://hdl.handle.net/2027.42/61338> | en_US |
dc.identifier.issn | 1861-4728 | en_US |
dc.identifier.issn | 1861-471X | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/61338 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=18712745&dopt=citation | en_US |
dc.description.abstract | The field of medicinal inorganic chemistry is rapidly advancing. In particular organometallic complexes have much potential as therapeutic and diagnostic agents. The carbon-bound and other ligands allow the thermodynamic and kinetic reactivity of the metal ion to be controlled and also provide a scaffold for functionalization. The establishment of structure–activity relationships and elucidation of the speciation of complexes under conditions relevant to drug testing and formulation are crucial for the further development of promising medicinal applications of organometallic complexes. Specific examples involving the design of ruthenium and osmium arene complexes as anticancer agents are discussed. | en_US |
dc.format.extent | 669358 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | WILEY-VCH Verlag | en_US |
dc.subject.other | Chemistry | en_US |
dc.subject.other | General Chemistry | en_US |
dc.title | Medicinal Organometallic Chemistry: Designing Metal Arene Complexes as Anticancer Agents | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Chemistry, University of Michigan, Ann Arbor, MI 48109-1055 (USA) | en_US |
dc.contributor.affiliationum | Department of Chemistry, University of Warwick, Coventry, CV4 7AL (UK), Fax: (+44) 24-765-23819 ; | en_US |
dc.identifier.pmid | 18712745 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/61338/1/1890_ftp.pdf | |
dc.identifier.doi | http://dx.doi.org/10.1002/asia.200800149 | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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