Now showing items 11-20 of 25
Un vivo depletion of murine CD8 positive T cells impairs survival during infection with a highly virulent strain of Cryptococcus neoformans
(Kluwer Academic Publishers; Springer Science+Business Media, 1994-01)
Cell-mediated immunity plays an important but incompletely understood role in host defense against Cryptococcus neoformans . Because of their multiple capacities as cytokine-secreting cells, cytotoxic cells, and antigen-specific ...
Calcitriol-mediated modulation of urokinase-type plasminogen activator and plasminogen activator inhibitor-2
(Elsevier, 1991-02-15)
Calcitriol-induced differentiation of U937 mononuclear phagocytes is known to have divergent effects on the synthesis of urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor-2 (PAI-2). In this ...
Differential dependence on protein kinase C of arachidonic acid metabolism stimulated by hydrogen peroxide and by zymosan in the alveolar macrophage
(Elsevier, 1990-11-12)
The dependence on protein kinase C (PKC) of arachidonic acid (AA) metabolism stimulated by the biologically important oxidant H2O2 as compared to zymosan particles, was investigated in the rat alveolar macrophage. The PKC ...
The oral gold compound auranofin triggers arachidonate release and cyclooxygenase metabolism in the alveolar macrophage
(Elsevier, 1988-12)
We examined the effect of in vitro incubation with the oral gold compound auranofin (AF) on arachidonic acid (AA) release and metabolism by rat alveolar macrophages (AMs). AF stimulated dose- and time-dependent release of ...
Inhibition of alveolar macrophage 5-lipoxygenase metabolism by auranofin
(Elsevier, 1989-05-15)
We have examined the effect of the oral gold compound auranofin (AF) on calcium ionophore A23187-induced arachidonic acid metabolism in the rat alveolar macrophage. Both reverse-phase high performance liquid Chromatographie ...
Reduced 5-lipoxygenase metabolism of arachidonic acid in macrophages rrom 1,25-dihydroxyvitamin D3-deficient rats
(Elsevier, 1994-11)
The peripheral blood monocyte (PBM) migrates into tissues and differentiates into mature tissue macrophages. Previous investigations from our laboratory have demonstrated that PBM have reduced 5-lipoxygenase (5-LO) metabolism ...
Pericellular proteolysis by leukocytes and tumor cells on substrates: focal activation and the role of urokinase-type plasminogen activator
(Springer-Verlag, 2004-04)
Previous studies have shown that the urokinase-type plasminogen activator receptor (uPAR) is localized to the adherence sites of leukocytes and tumor cells suggesting that pericellular proteolysis may accompany focal ...
Human neutrophils exhibit disparate chemotactic factor gene expression
(Elsevier, 1990-12-14)
The evolution of acute inflammation from initiation through resolution is associated with the changing character of the infiltrating leukocytes. Recruitment of these leukocytes is dependent upon the generation of chemotactic ...
Disparate regulation of interleukin 8 gene expression from blood monocytes, endothelial cells, and fibroblasts by interleukin 4
(Elsevier, 1990-09-14)
The role(s) of novel chemotactic cytokines as mediators in the pathogenesis of many acute and chronic disease states is becoming increasingly apparent. One of these cytokines, interleukin 8, is a product of both immune and ...
Absence of xanthine oxidase or xanthine dehydrogenase in the rabbit myocardium
(Elsevier, 1986-12-30)
We directly measured the activity of the enzymes xanthine oxidase and xanthine dehydrogenase in rabbit and rat hearts, using a sensitive radio-chemical assay. Neither xanthine oxidase activity nor xanthine dehydrogenase ...