Genome-wide linkage scan for prostate cancer susceptibility from the university of michigan prostate cancer genetics project: Suggestive evidence for linkage at 16q23
dc.contributor.author | Lange, Ethan M. | en_US |
dc.contributor.author | Beebe-Dimmer, Jennifer L. | en_US |
dc.contributor.author | Ray, Anna M. | en_US |
dc.contributor.author | Zuhlke, Kimberly A. | en_US |
dc.contributor.author | Ellis, Jaclyn | en_US |
dc.contributor.author | Wang, Yunfei | en_US |
dc.contributor.author | Walters, Sarah | en_US |
dc.contributor.author | Cooney, Kathleen A. | en_US |
dc.date.accessioned | 2009-02-03T16:17:19Z | |
dc.date.available | 2010-04-14T17:40:06Z | en_US |
dc.date.issued | 2009-03-01 | en_US |
dc.identifier.citation | Lange, Ethan M.; Beebe-Dimmer, Jennifer L.; Ray, Anna M.; Zuhlke, Kimberly A.; Ellis, Jaclyn; Wang, Yunfei; Walters, Sarah; Cooney, Kathleen A. (2009). "Genome-wide linkage scan for prostate cancer susceptibility from the university of michigan prostate cancer genetics project: Suggestive evidence for linkage at 16q23." The Prostate 69(4): 385-391. <http://hdl.handle.net/2027.42/61534> | en_US |
dc.identifier.issn | 0270-4137 | en_US |
dc.identifier.issn | 1097-0045 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/61534 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=19035517&dopt=citation | en_US |
dc.description.abstract | BACKGROUND Prostate cancer linkage studies have been used to localize rare and presumably highly penetrant cancer susceptibility genes. Underlying genetic heterogeneity, as well as the high sporadic background of the disease, has resulted in many signals that are often not reproducible between research studies. METHODS We conducted a SNP-based genome wide linkage scan on 131 Caucasian prostate cancer families participating in the University of Michigan Prostate Cancer Genetics Project (PCGP). RESULTS The strongest evidence for linkage was detected at 16q23 (LOD = 2.70 at rs1079635). Prostate cancer linkage to the same region of 16q23 has been observed by others and the region contains several strong candidate genes including the known prostate cancer tumor suppressor genes ATBF1 and WWOX . This linkage signal was not detected in our prior linkage study on 175 PCGP families, illustrating the genetic heterogeneity underlying prostate cancer susceptibility. CONCLUSIONS Further linkage studies in combination with tumor analyses from linked families are in progress to identify the putative hereditary prostate cancer gene at 16q23. Prostate 69:385–391, 2009. © 2008 Wiley-Liss, Inc. | en_US |
dc.format.extent | 140674 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cancer Research, Oncology and Pathology | en_US |
dc.title | Genome-wide linkage scan for prostate cancer susceptibility from the university of michigan prostate cancer genetics project: Suggestive evidence for linkage at 16q23 | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan ; Department of Internal Medicine and Urology, University of Michigan Medical School, Ann Arbor, Michigan ; Professor of Internal Medicine And Urology, University of Michigan Health System, 7216 Cancer Center, SPC 5948, 1500 East Medical Center Drive Ann Arbor, MI 48109. | en_US |
dc.contributor.affiliationother | Department of Genetics, University of North Carolina, Chapel Hill, North Carolina ; Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina ; The Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, North Carolina | en_US |
dc.contributor.affiliationother | Karmanos Cancer Institute, Detroit, Michigan ; Department of Internal Medicine, Wayne State University, Detroit, Michigan | en_US |
dc.contributor.affiliationother | The Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, North Carolina | en_US |
dc.contributor.affiliationother | Department of Genetics, University of North Carolina, Chapel Hill, North Carolina | en_US |
dc.identifier.pmid | 19035517 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/61534/1/20891_ftp.pdf | |
dc.identifier.doi | http://dx.doi.org/10.1002/pros.20891 | en_US |
dc.identifier.source | The Prostate | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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