An improved ultrasound-assisted extraction process of gossypol acetic acid from cottonseed soapstock
dc.contributor.author | Jia, Guangfeng | en_US |
dc.contributor.author | Zhan, Yonghua | en_US |
dc.contributor.author | Wu, Daocheng | en_US |
dc.contributor.author | Meng, Yang | en_US |
dc.contributor.author | Xu, Liang | en_US |
dc.date.accessioned | 2009-03-03T20:08:57Z | |
dc.date.available | 2010-04-14T17:40:05Z | en_US |
dc.date.issued | 2009-03 | en_US |
dc.identifier.citation | Jia, Guangfeng; Zhan, Yonghua; Wu, Daocheng; Meng, Yang; Xu, Liang (2009). "An improved ultrasound-assisted extraction process of gossypol acetic acid from cottonseed soapstock." AIChE Journal 55(3): 797-806. <http://hdl.handle.net/2027.42/61872> | en_US |
dc.identifier.issn | 0001-1541 | en_US |
dc.identifier.issn | 1547-5905 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/61872 | |
dc.description.abstract | To investigate the extracted process of gossypol acetic acid (G-AA) from cottonseed soapstock and explore the improvement of its yield and purity, a novel ultrasound-assisted extraction and crystallization method was introduced to this process. Under the optimized conditions, preliminary G-AA with the yield of 1300 mg and the purity of 95.9% could be obtained from 100 g of fresh soapstock by ultrasound-assisted extraction. In addition, UV, IR, and NMR spectrum further confirmed the detailed chemical structure of G-AA. Assay of inhibiting human prostate tumor cell line PC-3 and human breast cancer cell line MDA-MB-231 revealed its biological activity, the values of IC 50 are 9.096 Μmol/L and 14.37 Μmol/L respectively. In comparison with the conventional solvent extraction, this novel process increases the content of G-AA over 90%, reduces the time of crystallization by 75%, and retains the anticancer activity of gossypol. © 2009 American Institute of Chemical Engineers AIChE J, 2009 | en_US |
dc.format.extent | 218608 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Chemistry | en_US |
dc.subject.other | Chemical Engineering | en_US |
dc.title | An improved ultrasound-assisted extraction process of gossypol acetic acid from cottonseed soapstock | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Chemical Engineering | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Dept. of Radiation Oncology, Div. of Cancer Biology, University of Michigan, Ann Arbor, Michigan, MI 48103 | en_US |
dc.contributor.affiliationum | Dept. of Radiation Oncology, Div. of Cancer Biology, University of Michigan, Ann Arbor, Michigan, MI 48103 | en_US |
dc.contributor.affiliationother | Key Laboratory of Biomedical Information Engineering of Education Ministry, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China ; Institute of Natural Product Chemistry, Dept. of Chemistry, Shaanxi Institute of Education, Xi'an 710061, China | en_US |
dc.contributor.affiliationother | Key Laboratory of Biomedical Information Engineering of Education Ministry, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China | en_US |
dc.contributor.affiliationother | Key Laboratory of Biomedical Information Engineering of Education Ministry, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China ; Key Laboratory of Biomedical Information Engineering of Education Ministry, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/61872/1/11700_ftp.pdf | |
dc.identifier.doi | 10.1002/aic.11700 | en_US |
dc.identifier.source | AIChE Journal | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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