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A role for amygdaloid PKA and PKC in the acquisition of long-term conditional fear memories in rats

dc.contributor.authorGoosens, Ki A.
dc.contributor.authorHolt, William G.
dc.contributor.authorMaren, Stephen
dc.date.accessioned2009-03-23T18:34:02Z
dc.date.available2009-03-23T18:34:02Z
dc.date.issued2000-09
dc.identifier.citationBehavioural Brain Research, 114:145-52 <http://hdl.handle.net/2027.42/61935>en
dc.identifier.urihttps://hdl.handle.net/2027.42/61935
dc.description.abstractAlthough there is great interest in the cellular mechanisms underlying Pavlovian conditioning, few studies have directly examined the contribution of intracellular signaling pathways in the amygdala to the acquisition and expression of conditional fear memories. In the present study, we examined this issue by infusing 1-(5'-isoquinolinesulfonyl)-2-methylpiperazine (H7), a potent inhibitor of both protein kinase C (PKC) and cAMP-dependent protein kinase (PKA), directly into the amygdala prior to fear conditioning or retention testing. We found that infusion of H7 prior to training attenuated long-term conditional fear in a dose-dependent manner (Experiment 1), but short-term fear memories were spared. The contribution of protein kinases to conditional fear was region-specific within the amygdala: infusion of H7 into the basolateral amygdala (BLA) but not the central nucleus of the amygdala (CEA) resulted in attenuated freezing (Experiment 2). Moreover, the deficits in fear conditioning produced by PKA/PKC inhibition were not modality-specific, insofar as intra-BLA H7 reduced both contextual and auditory fear. The effects of H7 on conditional freezing were not attributable to either state-dependency or performance deficits (Experiment 3). Together, these experiments suggest that amygdaloid PKA and PKC play an important role in the acquisition of fear memories.en
dc.format.extent184618 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoen_USen
dc.titleA role for amygdaloid PKA and PKC in the acquisition of long-term conditional fear memories in ratsen
dc.typeArticleen
dc.subject.hlbsecondlevelPsychology
dc.subject.hlbtoplevelSocial Sciences
dc.description.peerreviewedPeer Revieweden
dc.contributor.affiliationumPsychology, Department ofen
dc.contributor.affiliationumcampusAnn Arboren
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/61935/1/goosensBBR00.pdf
dc.owningcollnamePsychology, Department of


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