NMDA receptors are essential for the acquisition, but not expression, of conditional fear and associative spike firing in the lateral amygdala
dc.contributor.author | Goosens, Ki A. | |
dc.contributor.author | Maren, Stephen | |
dc.date.accessioned | 2009-03-23T19:10:03Z | |
dc.date.available | 2009-03-23T19:10:03Z | |
dc.date.issued | 2004-07-15 | |
dc.identifier.citation | European Journal of Neuroscience, 20:537-48 <http://hdl.handle.net/2027.42/61956> | en |
dc.identifier.uri | https://hdl.handle.net/2027.42/61956 | |
dc.description.abstract | We examined the contribution of N-methyl-D-aspartate (NMDA) receptors (NMDARs) to the acquisition and expression of amygdaloid plasticity and Pavlovian fear conditioning using single-unit recording techniques in behaving rats. We demonstrate that NMDARs are essential for the acquisition of both behavioral and neuronal correlates of conditional fear, but play a comparatively limited role in their expression. Administration of the competitive NMDAR antagonist +/--3-(2-carboxypiperazin-4-yl) propyl-1-phosphonic acid (CPP) prior to auditory fear conditioning completely abolished the acquisition of conditional freezing and conditional single-unit activity in the lateral amygdala (LA). In contrast, CPP given prior to extinction testing did not affect the expression of conditional single-unit activity in LA, despite producing deficits in conditional freezing. Administration of CPP also blocked the induction of long-term potentiation in the amygdala. Together, these data suggest that NMDARs are essential for the acquisition of conditioning-related plasticity in the amygdala, and that NMDARs are more critical for regulating synaptic plasticity and learning than routine synaptic transmission in the circuitry supporting fear conditioning. | en |
dc.format.extent | 403110 bytes | |
dc.format.mimetype | application/pdf | |
dc.language.iso | en_US | en |
dc.title | NMDA receptors are essential for the acquisition, but not expression, of conditional fear and associative spike firing in the lateral amygdala | en |
dc.type | Article | en |
dc.subject.hlbsecondlevel | Psychology | |
dc.subject.hlbtoplevel | Social Sciences | |
dc.description.peerreviewed | Peer Reviewed | en |
dc.contributor.affiliationum | Psychology, Department of | en |
dc.contributor.affiliationum | Neuroscience Program | en |
dc.contributor.affiliationumcampus | Ann Arbor | en |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/61956/1/goosensEJN04pdf.pdf | |
dc.owningcollname | Psychology, Department of |
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