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Ventral hippocampal muscimol disrupts context-specific fear memory retrieval after extinction in rats

dc.contributor.authorHobin, Jennifer A.
dc.contributor.authorJi, Jinzhao
dc.contributor.authorMaren, Stephen
dc.date.accessioned2009-03-23T19:34:49Z
dc.date.available2009-03-23T19:34:49Z
dc.date.issued2006
dc.identifier.citationHippocampus, 16:174-82 <http://hdl.handle.net/2027.42/61971>en
dc.identifier.urihttps://hdl.handle.net/2027.42/61971
dc.description.abstractResearch aimed at understanding Pavlovian fear memory extinction has yielded considerable insight into the conditions under which fear memories may become inhibited. After extinction, Pavlovian fear memory retrieval is context-specific. Fear memories are not expressed in the extinction context, but they are expressed in every other context. Research indicates that the dorsal hippocampus mediates the context-specific expression of fear memory, but the role of the ventral hippocampus in mediating this process is unknown. Insofar as the ventral hippocampus is involved in the acquisition and expression of both context and tone fear, we asked whether GABA systems in the ventral hippocampus mediate context-specific fear memory retrieval after extinction. Experiment 1 showed that ventral hippocampal inactivation with muscimol disrupted context-specific fear memory retrieval. Experiment 2 showed that rats infused with muscimol can discriminate a context in which they were shocked from a neutral context. Nonetheless, they do appear to have a mild impairment in this task. Experiment 3 showed that ventral hippocampal muscimol did not disrupt locomotor activity, but did result in a slight increase in freezing and grooming, an effect that cannot explain the context-specific retrieval deficit demonstrated in experiment 1. These data are consistent with a role for the ventral hippocampus in mediating context-specific fear memory retrieval. Copyright 2005 Wiley-Liss, Inc.en
dc.format.extent205047 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoen_USen
dc.titleVentral hippocampal muscimol disrupts context-specific fear memory retrieval after extinction in ratsen
dc.typeArticleen
dc.subject.hlbsecondlevelPsychology
dc.subject.hlbtoplevelSocial Sciences
dc.description.peerreviewedPeer Revieweden
dc.contributor.affiliationumPsychology, Department ofen
dc.contributor.affiliationumNeuroscience Programen
dc.contributor.affiliationumcampusAnn Arboren
dc.identifier.pmid16358312en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/61971/1/hobinHIP06e.pdf
dc.owningcollnamePsychology, Department of


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