Pancreatic cancer stem cells and relevance to cancer treatments
dc.contributor.author | Bednar, Filip | en_US |
dc.contributor.author | Simeone, Diane M. | en_US |
dc.date.accessioned | 2009-05-04T18:24:17Z | |
dc.date.available | 2010-07-06T14:30:31Z | en_US |
dc.date.issued | 2009-05-01 | en_US |
dc.identifier.citation | Bednar, Filip; Simeone, Diane M. (2009). "Pancreatic cancer stem cells and relevance to cancer treatments." Journal of Cellular Biochemistry 107(1): 40-45. <http://hdl.handle.net/2027.42/62120> | en_US |
dc.identifier.issn | 0730-2312 | en_US |
dc.identifier.issn | 1097-4644 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/62120 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=19301275&dopt=citation | en_US |
dc.description.abstract | Pancreatic cancer continues to be a malignancy with few therapeutic options. The majority of patients that present for an evaluation have locally advanced or metastatic disease that is incurable by surgical approaches. Chemotherapy and radiotherapy resistance of pancreatic adenocarcinomas limits the efficacy of these therapeutic approaches. Recent evidence supports the existence of human pancreatic cancer stem cells, which appear to drive tumor initiation and progression and are particularly resistant to cell death induced by radiation or chemotherapy. Understanding the mechanisms of pancreatic cancer stem cell self-renewal and resistance to standard therapies may lead to new, more effective therapies to treat this dismal disease. J. Cell. Biochem. 107: 40–45, 2009. © 2009 Wiley-Liss, Inc. | en_US |
dc.format.extent | 100682 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cell & Developmental Biology | en_US |
dc.title | Pancreatic cancer stem cells and relevance to cancer treatments | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Genetics | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Surgery, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Surgery, University of Michigan, Ann Arbor, Michigan ; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan ; Professor, Departments of Surgery and Molecular and Integrative Physiology, University of Michigan Medical Center, TC 2210B, Box 5343, 1500 E. Medical Center Dr., Ann Arbor, MI 48109. | en_US |
dc.identifier.pmid | 19301275 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/62120/1/22093_ftp.pdf | |
dc.identifier.doi | 10.1002/jcb.22093 | en_US |
dc.identifier.source | Journal of Cellular Biochemistry | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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