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Pancreatic cancer stem cells and relevance to cancer treatments

dc.contributor.authorBednar, Filipen_US
dc.contributor.authorSimeone, Diane M.en_US
dc.date.accessioned2009-05-04T18:24:17Z
dc.date.available2010-07-06T14:30:31Zen_US
dc.date.issued2009-05-01en_US
dc.identifier.citationBednar, Filip; Simeone, Diane M. (2009). "Pancreatic cancer stem cells and relevance to cancer treatments." Journal of Cellular Biochemistry 107(1): 40-45. <http://hdl.handle.net/2027.42/62120>en_US
dc.identifier.issn0730-2312en_US
dc.identifier.issn1097-4644en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/62120
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=19301275&dopt=citationen_US
dc.description.abstractPancreatic cancer continues to be a malignancy with few therapeutic options. The majority of patients that present for an evaluation have locally advanced or metastatic disease that is incurable by surgical approaches. Chemotherapy and radiotherapy resistance of pancreatic adenocarcinomas limits the efficacy of these therapeutic approaches. Recent evidence supports the existence of human pancreatic cancer stem cells, which appear to drive tumor initiation and progression and are particularly resistant to cell death induced by radiation or chemotherapy. Understanding the mechanisms of pancreatic cancer stem cell self-renewal and resistance to standard therapies may lead to new, more effective therapies to treat this dismal disease. J. Cell. Biochem. 107: 40–45, 2009. © 2009 Wiley-Liss, Inc.en_US
dc.format.extent100682 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherCell & Developmental Biologyen_US
dc.titlePancreatic cancer stem cells and relevance to cancer treatmentsen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelGeneticsen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Surgery, University of Michigan, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartment of Surgery, University of Michigan, Ann Arbor, Michigan ; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan ; Professor, Departments of Surgery and Molecular and Integrative Physiology, University of Michigan Medical Center, TC 2210B, Box 5343, 1500 E. Medical Center Dr., Ann Arbor, MI 48109.en_US
dc.identifier.pmid19301275en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/62120/1/22093_ftp.pdf
dc.identifier.doi10.1002/jcb.22093en_US
dc.identifier.sourceJournal of Cellular Biochemistryen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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