Location of ectopic adrenocortical hormone-secreting tumors causing Cushing's syndrome in the paranasal sinuses
dc.contributor.author | Hodish, Israel | en_US |
dc.contributor.author | Giordano, Thomas J. | en_US |
dc.contributor.author | Starkman, Monica N. | en_US |
dc.contributor.author | Schteingart, David E. | en_US |
dc.date.accessioned | 2009-05-04T18:26:00Z | |
dc.date.available | 2010-07-06T14:30:31Z | en_US |
dc.date.issued | 2009-05 | en_US |
dc.identifier.citation | Hodish, Israel; Giordano, Thomas J.; Starkman, Monica N.; Schteingart, David E. (2009). "Location of ectopic adrenocortical hormone-secreting tumors causing Cushing's syndrome in the paranasal sinuses." Head & Neck 31(5): 699-706. <http://hdl.handle.net/2027.42/62139> | en_US |
dc.identifier.issn | 1043-3074 | en_US |
dc.identifier.issn | 1097-0347 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/62139 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=19031404&dopt=citation | en_US |
dc.description.abstract | Background. The majority of ectopic adrenocorticotropic hormone (ACTH)-secreting tumors are localized in the chest or abdomen. Occasionally, these tumors are found in the paranasal sinuses. Methods. We present 2 unusual cases of ectopic ACTH syndrome whose ACTH-secreting tumors were localized in the paranasal sinuses and describe their biochemical and radiological presentation. Results. The first patient had an ACTH-secreting olphactory neuroblastoma originating in the ethmoid sinuses. The second patient had a clinical course and biochemical findings indistinguishable from pituitary ACTH-dependent Cushing's syndrome, except for negative petrosal sinus sampling. Head imaging showed a “polyp” in the left maxillary sinus-secreting ACTH. Both patients went into remission following surgicalresection and recovered normal pituitary-adrenal axis function. Conclusion. Ectopic ACTH secretion may originate from lesions in the paranasal sinuses. This accessible location allows for direct immunohistochemical diagnosis with ACTH staining. Surgical resection/radiation therapy can result in complete remission of the disease and restoration of normal pituitary-adrenal function. © 2008 Wiley Periodicals, Inc. Head Neck, 2009. | en_US |
dc.format.extent | 361366 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cancer Research, Oncology and Pathology | en_US |
dc.title | Location of ectopic adrenocortical hormone-secreting tumors causing Cushing's syndrome in the paranasal sinuses | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Otolaryngology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, Michigan 48109 ; Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, Michigan 48109 | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Psychiatry, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, Michigan 48109 | en_US |
dc.identifier.pmid | 19031404 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/62139/1/20950_ftp.pdf | |
dc.identifier.doi | 10.1002/hed.20950 | en_US |
dc.identifier.source | Head & Neck | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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