Recombinant Fibroblast Growth Factor-i Promotes Intimal Hyperplasia And Angiogenesis In Arteries Invivo
dc.contributor.author | Nabel, Elizabeth G. | en_US |
dc.contributor.author | Yang, Zhi-Yong | en_US |
dc.contributor.author | Plautz, Gregory E. | en_US |
dc.contributor.author | Forough, R. | en_US |
dc.contributor.author | Zhan, X. | en_US |
dc.contributor.author | Haudenschild, Christian C. | en_US |
dc.contributor.author | Maciag, T. | en_US |
dc.contributor.author | Nabel, Gary J. | en_US |
dc.date.accessioned | 2009-06-01T17:29:25Z | |
dc.date.available | 2009-06-01T17:29:25Z | |
dc.date.issued | 1993-04-29 | en_US |
dc.identifier.citation | Nabel, EG; Yang, ZY; Plautz, G; Forough, R; Zhan, X; Haudenschild, CC; Maciag, T; Nabel, GJ. (1993) "Recombinant Fibroblast Growth Factor-i Promotes Intimal Hyperplasia And Angiogenesis In Arteries Invivo." Nature 362(6423): 844-846. <http://hdl.handle.net/2027.42/62656> | en_US |
dc.identifier.issn | 0028-0836 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/62656 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7683112&dopt=citation | en_US |
dc.description.abstract | THE prototype members of the heparin-binding fibroblast growth factor (FGF) family1-6, acidic FGF (FGF-1) and basic FGF (FGF-2), are among the growth factors that act directly on vascular cells to induce endothelial cell growth and angiogenesis. In vivo, the role of the FGF prototypes in vascular pathology has been difficult to determine. We report here the introduction, by direct gene transfer into porcine arteries, of a eukaryotic expression vector encoding a secreted form of FGF-1. This somatic transgenic model defines gene function in the arterial wall in vivo. FGF-1 expression induced intimal thickening in porcine arteries 21 days after gene transfer, in contrast to control arteries transduced with an Escherichia coli beta-galactosidase gene. Where there was substantial intimal hyperplasia, neocapillary formation was detected in the expanded intima. These findings suggest that FGF-1 induces intimal hyperplasia in the arterial wall in vivo and, through its ability to stimulate angiogenesis in the neointima, FGF-1 could stimulate neovascularization of atherosclerotic plaques. Potentially, gene transfer of FGF-1 could also be used as a genetic intervention to improve blood flow to ischaemic tissues in selected clinical settings. | en_US |
dc.format.extent | 530609 bytes | |
dc.format.extent | 2489 bytes | |
dc.format.mimetype | application/octet-stream | |
dc.format.mimetype | text/plain | |
dc.publisher | Macmillan Magazines Ltd. | en_US |
dc.source | Nature | en_US |
dc.title | Recombinant Fibroblast Growth Factor-i Promotes Intimal Hyperplasia And Angiogenesis In Arteries Invivo | en_US |
dc.type | Article | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | UNIV MICHIGAN,MED CTR,HOWARD HUGHES MED INST,DEPT BIOL CHEM,ANN ARBOR,MI 48109 | en_US |
dc.contributor.affiliationother | AMER RED CROSS,HOLLAND LAB,DEPT MOLEC BIOL,ROCKVILLE,MD 20855 | en_US |
dc.contributor.affiliationother | AMER RED CROSS,HOLLAND LAB,DEPT EXPTL PATHOL,ROCKVILLE,MD 20855 | en_US |
dc.identifier.pmid | 7683112 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/62656/1/362844a0.pdf | |
dc.identifier.doi | http://dx.doi.org/10.1038/362844a0 | en_US |
dc.identifier.source | Nature | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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