Show simple item record

Protective Effects Of Oligosaccharides In P-selectin-dependent Lung Injury

dc.contributor.authorMulligan, Michael S.en_US
dc.contributor.authorPaulson, James C.en_US
dc.contributor.authorDefrees, S.en_US
dc.contributor.authorZheng, Z. L.en_US
dc.contributor.authorLowe, John B.en_US
dc.contributor.authorWard, Peter A.en_US
dc.date.accessioned2009-06-01T17:33:51Z
dc.date.available2009-06-01T17:33:51Z
dc.date.issued1993-07-08en_US
dc.identifier.citationMulligan, MS; Paulson, JC; Defrees, S; Zheng, ZL; Lowe, JB; Ward, PA. (1993) "Protective Effects Of Oligosaccharides In P-selectin-dependent Lung Injury." Nature 364(6433): 149-151. <http://hdl.handle.net/2027.42/62725>en_US
dc.identifier.issn0028-0836en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/62725
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7686631&dopt=citationen_US
dc.description.abstractNEUTROPHIL recruitment into tissues is a multistep process involving sequential engagement of adhesion molecules, including selectins (E,P,L), which are reactive with oligosaccharides, and the family of beta2 integrins which are reactive with endothelial intercellular adhesion molecules1-3. These processes result in the initial rolling of leukocytes along the endothelial surfaces, followed by the firm attachment of leukocytes to the endothelium. The intravenous infusion of cobra venom factor into rats results in acute lung injury that is neutrophil-dependent, oxygen radical mediated and P-selectin-dependent4,5. Here we report that infusion of sialyl-Lewis X, a ligand for P-selectin6-9, dramatically reduced lung injury and diminished the tissue accumulation of neutrophils, whereas irrelevant oligosaccharides had no such effects. These results suggest that sialyl-Lewis X carbohydrates maybe used as a new strategy for anti-inflammatory therapy.en_US
dc.format.extent444257 bytes
dc.format.extent2489 bytes
dc.format.mimetypeapplication/octet-stream
dc.format.mimetypetext/plain
dc.publisherMacmillan Magazines Ltd.en_US
dc.sourceNatureen_US
dc.titleProtective Effects Of Oligosaccharides In P-selectin-dependent Lung Injuryen_US
dc.typeArticleen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumUNIV MICHIGAN,SCH MED,DEPT PATHOL,1301 CATHERINE RD,ANN ARBOR,MI 48109en_US
dc.contributor.affiliationumUNIV MICHIGAN,SCH MED,HOWARD HUGHES MED INST,ANN ARBOR,MI 48109en_US
dc.contributor.affiliationotherCYTEL CORP,SAN DIEGO,CA 92121en_US
dc.identifier.pmid7686631en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/62725/1/364149a0.pdf
dc.identifier.doihttp://dx.doi.org/10.1038/364149a0en_US
dc.identifier.sourceNatureen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


Files in this item

Show simple item record

Remediation of Harmful Language

The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.

Accessibility

If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.