Increased bone formation in osteocalcin-deficient mice
dc.contributor.author | Ducy, P. | en_US |
dc.contributor.author | Desbois, C. | en_US |
dc.contributor.author | Boyce, B. | en_US |
dc.contributor.author | Pinero, G. | en_US |
dc.contributor.author | Story, B. | en_US |
dc.contributor.author | Dunstan, C. R. | en_US |
dc.contributor.author | Smith, Erica | en_US |
dc.contributor.author | Bonadio, Jeffrey F. | en_US |
dc.contributor.author | Goldstein, S. | en_US |
dc.contributor.author | Gundberg, C. | en_US |
dc.contributor.author | Bradley, A. | en_US |
dc.contributor.author | Karsenty, Gerard | en_US |
dc.date.accessioned | 2009-06-01T17:34:07Z | |
dc.date.available | 2009-06-01T17:34:07Z | |
dc.date.issued | 1996-08-01 | en_US |
dc.identifier.citation | Ducy, P; Desbois, C; Boyce, B; Pinero, G; Story, B; Dunstan, C; Smith, E; Bonadio, J; Goldstein, S; Gundberg, C; Bradley, A; Karsenty, G. (1996) "Increased bone formation in osteocalcin-deficient mice." Nature 382(6590): 448-452. <http://hdl.handle.net/2027.42/62730> | en_US |
dc.identifier.issn | 0028-0836 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/62730 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8684484&dopt=citation | en_US |
dc.description.abstract | VERTEBRATES constantly remodel bone. The resorption of preexisting bone by osteoclasts and the formation of new hone by osteoblasts is strictly coordinated to maintain bone mass within defined limits. A fen molecular determinants of bone remodelling that affect osteoclast activity(1-3) have been characterized, bot the molecular determinants of osteoblast activity are unknown. To investigate the role of osteocalcin, the most abundant osteoblast-specific non-collagenous protein(4) we have generated osteocalcin-deficient mice. These mice develop a phenotype marked by higher bone mass and bones of Improved functional quality. Histomorphometric studies done before and after ovariectomy showed that the absence of osteocalcin leads to an increase in bone formation without impairing bone resorption. To our knowledge, this study provides the first evidence that osteocalcin is a determinant of bone formation. | en_US |
dc.format.extent | 1383665 bytes | |
dc.format.extent | 2489 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Macmillan Magazines Ltd. | en_US |
dc.source | Nature | en_US |
dc.title | Increased bone formation in osteocalcin-deficient mice | en_US |
dc.type | Article | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | UNIV MICHIGAN,SCH MED,DEPT ORTHOPAED,ANN ARBOR,MI 48109 | en_US |
dc.contributor.affiliationum | UNIV MICHIGAN,SCH MED,DEPT PATHOL,ANN ARBOR,MI 48109 | en_US |
dc.contributor.affiliationother | UNIV TEXAS,MD ANDERSON CANC CTR,DEPT MOL GENET,HOUSTON,TX 77030 | en_US |
dc.contributor.affiliationother | UNIV TEXAS,HLTH SCI CTR,DEPT PATHOL,SAN ANTONIO,TX 78284 | en_US |
dc.contributor.affiliationother | UNIV TEXAS,HLTH SCI CTR,DEPT MED,SAN ANTONIO,TX 78284 | en_US |
dc.contributor.affiliationother | UNIV TEXAS,DENT BRANCH,DEPT BASIC SCI,HOUSTON,TX 77030 | en_US |
dc.contributor.affiliationother | YALE UNIV,SCH MED,DEPT ORTHOPAED,NEW HAVEN,CT 06510 | en_US |
dc.contributor.affiliationother | BAYLOR COLL MED,HOWARD HUGHES MED INST,HOUSTON,TX 77030 | en_US |
dc.contributor.affiliationother | BAYLOR COLL MED,DEPT MOL & HUMAN GENET,HOUSTON,TX 77030 | en_US |
dc.identifier.pmid | 8684484 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/62730/1/382448a0.pdf | |
dc.identifier.doi | http://dx.doi.org/10.1038/382448a0 | en_US |
dc.identifier.source | Nature | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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