From endoplasmic-reticulum stress to the inflammatory response
dc.contributor.author | Zhang, Kezhong | en_US |
dc.contributor.author | Kaufman, Randal J. | en_US |
dc.date.accessioned | 2009-06-01T17:34:50Z | |
dc.date.available | 2009-06-01T17:34:50Z | |
dc.date.issued | 2008-07-24 | en_US |
dc.identifier.citation | Zhang, Kezhong; Kaufman, Randal J.. (2008) "From endoplasmic-reticulum stress to the inflammatory response." Nature 454(7203): 455-462. <http://hdl.handle.net/2027.42/62741> | en_US |
dc.identifier.issn | 0028-0836 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/62741 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=18650916&dopt=citation | en_US |
dc.description.abstract | The endoplasmic reticulum is responsible for much of a cell's protein synthesis and folding, but it also has an important role in sensing cellular stress. Recently, it has been shown that the endoplasmic reticulum mediates a specific set of intracellular signalling pathways in response to the accumulation of unfolded or misfolded proteins, and these pathways are collectively known as the unfolded-protein response. New observations suggest that the unfolded-protein response can initiate inflammation, and the coupling of these responses in specialized cells and tissues is now thought to be fundamental in the pathogenesis of inflammatory diseases. The knowledge gained from this emerging field will aid in the development of therapies for modulating cellular stress and inflammation. | en_US |
dc.format.extent | 1347365 bytes | |
dc.format.extent | 2489 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Nature Publishing Group | en_US |
dc.source | Nature | en_US |
dc.title | From endoplasmic-reticulum stress to the inflammatory response | en_US |
dc.type | Article | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Kaufman, Randal J.] Univ Michigan, Med Ctr, Dept Biol Chem, Ann Arbor, MI 48109 USA | en_US |
dc.contributor.affiliationum | [Kaufman, Randal J.] Univ Michigan, Med Ctr, Dept Internal Med, Ann Arbor, MI 48109 USA | en_US |
dc.contributor.affiliationum | [Kaufman, Randal J.] Univ Michigan, Med Ctr, Howard Hughes Med Inst, Ann Arbor, MI 48109 USA | en_US |
dc.contributor.affiliationother | [Zhang, Kezhong | en_US |
dc.identifier.pmid | 18650916 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/62741/1/nature07203.pdf | |
dc.identifier.doi | http://dx.doi.org/10.1038/nature07203 | en_US |
dc.identifier.source | Nature | en_US |
dc.contributor.authoremail | kaufmanr@umich.edu | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.