Expression Of Anti-dna Immunoglobulin Transgenes In Non-autoimmune Mice
dc.contributor.author | Erikson, J. | en_US |
dc.contributor.author | Radic, M. Z. | en_US |
dc.contributor.author | Camper, Sally A. | en_US |
dc.contributor.author | Hardy, R. R. | en_US |
dc.contributor.author | Carmack, C. | en_US |
dc.contributor.author | Weigert, M. | en_US |
dc.date.accessioned | 2009-06-01T17:40:18Z | |
dc.date.available | 2009-06-01T17:40:18Z | |
dc.date.issued | 1991-01-24 | en_US |
dc.identifier.citation | Erikson, J; Radic, MZ; Camper, SA; Hardy, RR; Carmack, C; Weigert, M. (1991) "Expression Of Anti-dna Immunoglobulin Transgenes In Non-autoimmune Mice." Nature 349(6307): 331-334. <http://hdl.handle.net/2027.42/62839> | en_US |
dc.identifier.issn | 0028-0836 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/62839 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1898987&dopt=citation | en_US |
dc.description.abstract | SELF-REACTIVE B cells can be regulated by either deletion or inactivation 1. These manifestations of self-tolerance have been dramatically shown in transgenic mice in which the number of self-reactive cells has been artificially expanded 2,3. We have now extended these models to ask if B-cell tolerance as described for non-disease-associated antigens also operates for the targets of autoimmunity. The target we have chosen is DNA. Anti-DNA antibodies are diagnostic of certain autoimmune syndromes in humans and are a characteristic of the murine model of systemic autoimmunity, the MRI/Ipr mouse4. Antibodies to both single-stranded and double-stranded DNA have been implicated in disease 5,6. By generating anti-DNA transgenic mice, we have addressed the question of whether DNA-specific B cells are regulated in normal (non-autoimmune) mice. We indeed found that most transgenic B cells bind DNA, yet we failed to detect secreted anti-DNA. We suggest that as a consequence of their self-reactivity these B cells are developmentally arrested. | en_US |
dc.format.extent | 661085 bytes | |
dc.format.extent | 2489 bytes | |
dc.format.mimetype | application/octet-stream | |
dc.format.mimetype | text/plain | |
dc.publisher | Macmillan Magazines Ltd. | en_US |
dc.source | Nature | en_US |
dc.title | Expression Of Anti-dna Immunoglobulin Transgenes In Non-autoimmune Mice | en_US |
dc.type | Article | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | UNIV MICHIGAN,SCH MED,DEPT HUMAN GENET,ANN ARBOR,MI 48109 | en_US |
dc.identifier.pmid | 1898987 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/62839/1/349331a0.pdf | |
dc.identifier.doi | http://dx.doi.org/10.1038/349331a0 | en_US |
dc.identifier.source | Nature | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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