RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems
dc.contributor.author | Kobayashi, K. | en_US |
dc.contributor.author | Inohara, Naohiro | en_US |
dc.contributor.author | Hernandez, L. D. | en_US |
dc.contributor.author | Galan, J. E. | en_US |
dc.contributor.author | Nunez, Gabriel | en_US |
dc.contributor.author | Janeway, C. A. | en_US |
dc.contributor.author | Medzhitov, R. | en_US |
dc.contributor.author | Flavell, R. A. | en_US |
dc.date.accessioned | 2009-06-01T17:40:28Z | |
dc.date.available | 2009-06-01T17:40:28Z | |
dc.date.issued | 2002-03-14 | en_US |
dc.identifier.citation | Kobayashi, K; Inohara, N; Hernandez, LD; Galan, JE; Nunez, G; Janeway, CA; Medzhitov, R; Flavell, RA. (2002) "RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems." Nature 416(6877): 194-199. <http://hdl.handle.net/2027.42/62842> | en_US |
dc.identifier.issn | 0028-0836 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/62842 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=11894098&dopt=citation | en_US |
dc.description.abstract | The immune system consists of two evolutionarily different but closely related responses, innate immunity and adaptive immunity. Each of these responses has characteristic receptors-Toll-like receptors (TLRs) for innate immunity and antigen-specific receptors for adaptive immunity. Here we show that the caspase recruitment domain (CARD)-containing serine/threonine kinase Rip2 (also known as RICK, CARDIAK, CCK and Ripk2)(1-4) transduces signals from receptors of both immune responses. Rip2 was recruited to TLR2 signalling complexes after ligand stimulation. Moreover, cytokine production in Rip2-deficient cells was reduced on stimulation of TLRs with lipopolysaccharide, peptidoglycan and double-stranded RNA, but not with bacterial DNA, indicating that Rip2 is downstream of TLR2/3/4 but not TLR9. Rip2-deficient cells were also hyporesponsive to signalling through interleukin (IL)-1 and IL-18 receptors, and deficient for signalling through Nod proteins-molecules also implicated in the innate immune response. Furthermore, Rip2-deficient T cells showed severely reduced NF-kappaB activation, IL-2 production and proliferation on T-cell-receptor (TCR) engagement, and impaired differentiation to T-helper subtype 1 (T(H)1) cells, indicating that Rip2 is required for optimal TCR signalling and T-cell differentiation. Rip2 is therefore a signal transducer and integrator of signals for both the innate and adaptive immune systems. | en_US |
dc.format.extent | 366462 bytes | |
dc.format.extent | 2489 bytes | |
dc.format.mimetype | application/octet-stream | |
dc.format.mimetype | text/plain | |
dc.publisher | Nature Publishing Group | en_US |
dc.source | Nature | en_US |
dc.title | RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems | en_US |
dc.type | Article | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA | en_US |
dc.contributor.affiliationum | Univ Michigan, Sch Med, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA | en_US |
dc.contributor.affiliationother | Yale Univ, Sch Med, Immunobiol Sect, New Haven, CT 06520 USA | en_US |
dc.contributor.affiliationother | Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06520 USA | en_US |
dc.contributor.affiliationother | Yale Univ, Sch Med, Boyer Ctr Mol Med, Ctr Microbial Pathogenesis, New Haven, CT 06536 USA | en_US |
dc.identifier.pmid | 11894098 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/62842/1/416194a.pdf | |
dc.identifier.doi | http://dx.doi.org/10.1038/416194a | en_US |
dc.identifier.source | Nature | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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