Homology Of A Candidate Spermatogenic Gene From The Mouse Y-chromosome To The Ubiquitin-activating Enzyme-e1
dc.contributor.author | Mitchell, M. J. | en_US |
dc.contributor.author | Woods, Diane R. | en_US |
dc.contributor.author | Tucker, P. K. | en_US |
dc.contributor.author | Opp, J. S. | en_US |
dc.contributor.author | Bishop, C. E. | en_US |
dc.date.accessioned | 2009-06-01T17:40:40Z | |
dc.date.available | 2009-06-01T17:40:40Z | |
dc.date.issued | 1991-12-12 | en_US |
dc.identifier.citation | Mitchell, MJ; Woods, DR; Tucker, PK; Opp, JS; Bishop, CE. (1991) "Homology Of A Candidate Spermatogenic Gene From The Mouse Y-chromosome To The Ubiquitin-activating Enzyme-e1." Nature 354(6353): 483-486. <http://hdl.handle.net/2027.42/62846> | en_US |
dc.identifier.issn | 0028-0836 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/62846 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1684224&dopt=citation | en_US |
dc.description.abstract | THE Sxr (sex-reversed) region, a fragment of the Y chromosome short arm, can cause chromosomally female XXSxr or XSxrO mice to develop as sterile males 1-3. The original Sxr region, termed Sxr(a), encodes: Tdy, the primary sex-determining gene; Hya, the controlling or structural locus for the minor transplantation antigen H-Y (ref. 4); gene(s) controlling the expression of the serologically detected male antigen (SDMA) 5; Spy, a gene(s) required for the survival and proliferation of A spermatogonia during spermatogenesis 6,7; Zfy-1/Zfy-2, zinc-finger-containing genes of unknown function 8; and Sry, which is probably identical to Tdy (ref. 9). A deletion variant 10 of Sxr(a), termed Sxr(b), which lacks Hya, SDMA expression, Spy and some Zfy-2 sequences, makes positional cloning of these genes possible. We report here the isolation of a new testis-specific gene, Sby, mapping to the DNA deleted from the Sxr(b) region (the DELTA-Sxr(b) interval). Sby has extensive homology to the X-linked human ubiquitin-activating enzyme E1 (ref. 11). The critical role of this enzyme in nuclear DNA replication 12 together with the testis-specific expression of Sby suggests Sby as a candidate for the spermatogenic gene Spy. | en_US |
dc.format.extent | 830335 bytes | |
dc.format.extent | 2489 bytes | |
dc.format.mimetype | application/octet-stream | |
dc.format.mimetype | text/plain | |
dc.publisher | Macmillan Magazines Ltd. | en_US |
dc.source | Nature | en_US |
dc.title | Homology Of A Candidate Spermatogenic Gene From The Mouse Y-chromosome To The Ubiquitin-activating Enzyme-e1 | en_US |
dc.type | Article | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | UNIV MICHIGAN,MUSEUM ZOOL,ANN ARBOR,MI 48109 | en_US |
dc.contributor.affiliationum | UNIV MICHIGAN,DEPT BIOL,ANN ARBOR,MI 48109 | en_US |
dc.contributor.affiliationother | INST PASTEUR,INSERM,U276,UNITE IMMUNOGENET HUMAINE,PARIS 15,FRANCE | en_US |
dc.identifier.pmid | 1684224 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/62846/1/354483a0.pdf | |
dc.identifier.doi | http://dx.doi.org/10.1038/354483a0 | en_US |
dc.identifier.source | Nature | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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