Delineation of prognostic biomarkers in prostate cancer
dc.contributor.author | Dhanasekaran, Saravana M. | en_US |
dc.contributor.author | Barrette, T. R. | en_US |
dc.contributor.author | Ghosh, Debashis | en_US |
dc.contributor.author | Shah, Rajal B. | en_US |
dc.contributor.author | Varambally, Sooryanarayana | en_US |
dc.contributor.author | Kurachi, K. | en_US |
dc.contributor.author | Pienta, Kenneth J. | en_US |
dc.contributor.author | Rubin, Mark A. | en_US |
dc.contributor.author | Chinnaiyan, Arul M. | en_US |
dc.date.accessioned | 2009-06-01T17:40:50Z | |
dc.date.available | 2009-06-01T17:40:50Z | |
dc.date.issued | 2001-08-23 | en_US |
dc.identifier.citation | Dhanasekaran, SM; Barrette, TR; Ghosh, D; Shah, R; Varambally, S; Kurachi, K; Pienta, KJ; Rubin, MA; Chinnaiyan, AM. (2001) "Delineation of prognostic biomarkers in prostate cancer." Nature 412(6849): 822-826. <http://hdl.handle.net/2027.42/62849> | en_US |
dc.identifier.issn | 0028-0836 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/62849 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=11518967&dopt=citation | en_US |
dc.description.abstract | Prostate cancer is the most frequently diagnosed cancer in American men(1,2). Screening for prostate-specific antigen (PSA) has led to earlier detection of prostate cancer(3), but elevated serum PSA levels may be present in non-malignant conditions such as benign prostatic hyperlasia (BPH). Characterization of gene-expression profiles that molecularly distinguish prostatic neoplasms may identify genes involved in prostate carcinogenesis, elucidate clinical biomarkers, and lead to an improved classification of prostate cancer(4-6). Using microarrays of complementary DNA, we examined gene-expression profiles of more than 50 normal and neoplastic prostate specimens and three common prostate-cancer cell lines. Signature expression profiles of normal adjacent prostate (NAP), BPH, localized prostate cancer, and metastatic, hormone-refractory prostate cancer were determined. Here we establish many associations between genes and prostate cancer. We assessed two of these genes-hepsin, a transmembrane serine protease, and pim-1, a serine/threonine kinase-at the protein level using tissue microarrays consisting of over 700 clinically stratified prostate-cancer specimens. Expression of hepsin and pim-1 proteins was significantly correlated with measures of clinical outcome. Thus, the integration of cDNA microarray, high-density tissue microarray, and linked clinical and pathology data is a powerful approach to molecular profiling of human cancer. | en_US |
dc.format.extent | 426205 bytes | |
dc.format.extent | 2489 bytes | |
dc.format.mimetype | application/octet-stream | |
dc.format.mimetype | text/plain | |
dc.publisher | Macmillan Publishers Ltd. | en_US |
dc.source | Nature | en_US |
dc.title | Delineation of prognostic biomarkers in prostate cancer | en_US |
dc.type | Article | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA | en_US |
dc.contributor.affiliationum | Univ Michigan, Sch Med, Dept Biostat, Ann Arbor, MI 48109 USA | en_US |
dc.contributor.affiliationum | Univ Michigan, Sch Med, Dept Human Genet, Ann Arbor, MI 48109 USA | en_US |
dc.contributor.affiliationum | Univ Michigan, Sch Med, Dept Urol, Ann Arbor, MI 48109 USA | en_US |
dc.contributor.affiliationum | Univ Michigan, Sch Med, Dept Internal Med, Ann Arbor, MI 48109 USA | en_US |
dc.contributor.affiliationum | Univ Michigan, Sch Med, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA | en_US |
dc.identifier.pmid | 11518967 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/62849/1/412822a0.pdf | |
dc.identifier.doi | http://dx.doi.org/10.1038/35090585 | en_US |
dc.identifier.source | Nature | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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