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Stem cells, cancer, and cancer stem cells

dc.contributor.authorReya, T.en_US
dc.contributor.authorMorrison, Sean J.en_US
dc.contributor.authorClarke, Michael. F.en_US
dc.contributor.authorWeissman, Irving L.en_US
dc.date.accessioned2009-06-01T17:41:32Z
dc.date.available2009-06-01T17:41:32Z
dc.date.issued2001-11-01en_US
dc.identifier.citationReya, T; Morrison, SJ; Clarke, MF; Weissman, IL. (2001) "Stem cells, cancer, and cancer stem cells." Nature 414(6859): 105-111. <http://hdl.handle.net/2027.42/62862>en_US
dc.identifier.issn0028-0836en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/62862
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=11689955&dopt=citationen_US
dc.description.abstractStem cell biology has come of age. Unequivocal proof that stem cells exist in the haematopoietic system has given way to the prospective isolation of several tissue-specific stem and progenitor cells, the initial delineation of their properties and expressed genetic programmes, and the beginnings of their utility in regenerative medicine. Perhaps the most important and useful property of stem cells is that of self-renewal. Through this property, striking parallels can be found between stem cells and cancer cells: tumours may often originate from the transformation of normal stem cells, similar signalling pathways may regulate self-renewal in stem cells and cancer cells, and cancer cells may include 'cancer stem cells'-rare cells with indefinite potential for self-renewal that drive tumorigenesis.en_US
dc.format.extent652956 bytes
dc.format.extent2489 bytes
dc.format.mimetypeapplication/octet-stream
dc.format.mimetypetext/plain
dc.publisherMacmillan Publishers Ltd.en_US
dc.sourceNatureen_US
dc.titleStem cells, cancer, and cancer stem cellsen_US
dc.typeArticleen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumUniv Michigan, Howard Hughes Med Inst, Ann Arbor, MI 48109 USAen_US
dc.contributor.affiliationumUniv Michigan, Dept Internal Med, Ann Arbor, MI 48109 USAen_US
dc.contributor.affiliationotherStanford Univ, Sch Med, Dept Dev Biol, Stanford, CA 94305 USAen_US
dc.contributor.affiliationotherStanford Univ, Sch Med, Dept Pathol, Stanford, CA 94305 USAen_US
dc.identifier.pmid11689955en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/62862/1/414105a0.pdf
dc.identifier.doihttp://dx.doi.org/10.1038/35102167en_US
dc.identifier.sourceNatureen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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