A first-generation linkage disequilibrium map of human chromosome 22
dc.contributor.author | Dawson, E. | en_US |
dc.contributor.author | Abecasis, Gonçalo R. | en_US |
dc.contributor.author | Bumpstead, S. | en_US |
dc.contributor.author | Chen, Yuan | en_US |
dc.contributor.author | Hunt, Sarah | en_US |
dc.contributor.author | Beare, D. M. | en_US |
dc.contributor.author | Pabial, J. | en_US |
dc.contributor.author | Dibling, T. | en_US |
dc.contributor.author | Tinsley, E. | en_US |
dc.contributor.author | Kirby, S. | en_US |
dc.contributor.author | Carter, David. | en_US |
dc.contributor.author | Papaspyridonos, M. | en_US |
dc.contributor.author | Livingstone, S. | en_US |
dc.contributor.author | Ganske, R. | en_US |
dc.contributor.author | Lohmmussaar, E. | en_US |
dc.contributor.author | Zernant, J. | en_US |
dc.contributor.author | Tonisson, N. | en_US |
dc.contributor.author | Remm, M. | en_US |
dc.contributor.author | Magi, R. | en_US |
dc.contributor.author | Puurand, T. | en_US |
dc.contributor.author | Vilo, J. | en_US |
dc.contributor.author | Kurg, A. | en_US |
dc.contributor.author | Rice, Kate | en_US |
dc.contributor.author | Deloukas, Panos | en_US |
dc.contributor.author | Mott, R. | en_US |
dc.contributor.author | Metspalu, A. | en_US |
dc.contributor.author | Bentley, David R. | en_US |
dc.contributor.author | Cardon, L. R. | en_US |
dc.contributor.author | Dunham, I. | en_US |
dc.date.accessioned | 2009-06-01T17:42:39Z | |
dc.date.available | 2009-06-01T17:42:39Z | |
dc.date.issued | 2002-08-01 | en_US |
dc.identifier.citation | Dawson, E; Abecasis, GR; Bumpstead, S; Chen, Y; Hunt, S; Beare, DM; Pabial, J; Dibling, T; Tinsley, E; Kirby, S; Carter, D; Papaspyridonos, M; Livingstone, S; Ganske, R; Lohmmussaar, E; Zernant, J; Tonisson, N; Remm, M; Magi, R; Puurand, T; Vilo, J; Kurg, A; Rice, K; Deloukas, P; Mott, R; Metspalu, A; Bentley, DR; Cardon, LR; Dunham, I. (2002) "A first-generation linkage disequilibrium map of human chromosome 22." Nature 418(6897): 544-548. <http://hdl.handle.net/2027.42/62882> | en_US |
dc.identifier.issn | 0028-0836 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/62882 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=12110843&dopt=citation | en_US |
dc.description.abstract | DNA sequence variants in specific genes or regions of the human genome are responsible for a variety of phenotypes such as disease risk or variable drug response(1). These variants can be investigated directly, or through their non-random associations with neighbouring markers (called linkage disequilibrium (LD))(2-8). Here we report measurement of LD along the complete sequence of human chromosome 22. Duplicate genotyping and analysis of 1,504 markers in Centre d'Etude du Polymorphisme Humain (CEPH) reference families at a median spacing of 15 kilobases (kb) reveals a highly variable pattern of LD along the chromosome, in which extensive regions of nearly complete LD up to 804 kb in length are interspersed with regions of little or no detectable LD. The LD patterns are replicated in a panel of unrelated UK Caucasians. There is a strong correlation between high LD and low recombination frequency in the extant genetic map, suggesting that historical and contemporary recombination rates are similar. This study demonstrates the feasibility of developing genome-wide maps of LD. | en_US |
dc.format.extent | 674938 bytes | |
dc.format.extent | 2489 bytes | |
dc.format.mimetype | application/octet-stream | |
dc.format.mimetype | text/plain | |
dc.publisher | Nature Publishing Group | en_US |
dc.source | Nature | en_US |
dc.title | A first-generation linkage disequilibrium map of human chromosome 22 | en_US |
dc.type | Article | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA | en_US |
dc.contributor.affiliationother | Wellcome Trust Sanger Inst, Cambridge CB10 1SA, England | en_US |
dc.contributor.affiliationother | Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England | en_US |
dc.contributor.affiliationother | Third Wave Technol Inc, Madison, WI 53719 USA | en_US |
dc.contributor.affiliationother | Univ Tartu, IMCB, EE-51010 Tartu, Estonia | en_US |
dc.contributor.affiliationother | Univ Tartu, Estonian Bioctr, EE-51010 Tartu, Estonia | en_US |
dc.contributor.affiliationother | Asper Ltd, EE-51014 Tartu, Estonia | en_US |
dc.contributor.affiliationother | European Bioinformat Inst, Cambridge CB10 1SD, England | en_US |
dc.identifier.pmid | 12110843 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/62882/1/nature00864.pdf | |
dc.identifier.doi | http://dx.doi.org/10.1038/nature00864 | en_US |
dc.identifier.source | Nature | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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