The equilibria that allow bacterial persistence in human hosts
dc.contributor.author | Blaser, Martin J. | en_US |
dc.contributor.author | Kirschner, Denise E. | en_US |
dc.date.accessioned | 2009-06-01T17:42:43Z | |
dc.date.available | 2009-06-01T17:42:43Z | |
dc.date.issued | 2007-10-18 | en_US |
dc.identifier.citation | Blaser, Martin J.; Kirschner, Denise. (2007) "The equilibria that allow bacterial persistence in human hosts." Nature 449(7164): 843-849. <http://hdl.handle.net/2027.42/62883> | en_US |
dc.identifier.issn | 0028-0836 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/62883 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=17943121&dopt=citation | en_US |
dc.description.abstract | We propose that microbes that have developed persistent relationships with human hosts have evolved cross-signalling mechanisms that permit homeostasis that conforms to Nash equilibria and, more specifically, to evolutionarily stable strategies. This implies that a group of highly diverse organisms has evolved within the changing contexts of variation in effective human population size and lifespan, shaping the equilibria achieved, and creating relationships resembling climax communities. We propose that such ecosystems contain nested communities in which equilibrium at one level contributes to homeostasis at another. The model can aid prediction of equilibrium states in the context of further change: widespread immunodeficiency, changing population densities, or extinctions. | en_US |
dc.format.extent | 251584 bytes | |
dc.format.extent | 2489 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Nature Publishing Group | en_US |
dc.source | Nature | en_US |
dc.title | The equilibria that allow bacterial persistence in human hosts | en_US |
dc.type | Article | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Univ Michigan, Sch Med, Dept Microbiol & Immunol, Ann Arbor, MI 48109 USA | en_US |
dc.contributor.affiliationother | NYU, Sch Med, Dept Med, New York, NY 10016 USA | en_US |
dc.contributor.affiliationother | NYU, Sch Med, Dept Microbiol, New York, NY 10016 USA | en_US |
dc.identifier.pmid | 17943121 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/62883/1/nature06198.pdf | |
dc.identifier.doi | http://dx.doi.org/10.1038/nature06198 | en_US |
dc.identifier.source | Nature | en_US |
dc.contributor.authoremail | martin.blaser@med.nyu.edu | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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