The polycomb group protein EZH2 is involved in progression of prostate cancer
dc.contributor.author | Varambally, Sooryanarayana | en_US |
dc.contributor.author | Dhanasekaran, Saravana M. | en_US |
dc.contributor.author | Zhou, M. | en_US |
dc.contributor.author | Barrette, T. R. | en_US |
dc.contributor.author | Kumar-Sinha, C. | en_US |
dc.contributor.author | Sanda, Martin G. | en_US |
dc.contributor.author | Ghosh, Debashis | en_US |
dc.contributor.author | Pienta, Kenneth J. | en_US |
dc.contributor.author | Sewalt, Rgab | en_US |
dc.contributor.author | Otte, A. P. | en_US |
dc.contributor.author | Rubin, Mark A. | en_US |
dc.contributor.author | Chinnaiyan, Arul M. | en_US |
dc.date.accessioned | 2009-06-01T17:43:26Z | |
dc.date.available | 2009-06-01T17:43:26Z | |
dc.date.issued | 2002-10-10 | en_US |
dc.identifier.citation | Varambally, S; Dhanasekaran, SM; Zhou, M; Barrette, TR; Kumar-Sinha, C; Sanda, MG; Ghosh, D; Pienta, KJ; Sewalt, RGAB; Otte, AP; Rubin, MA; Chinnaiyan, AM. (2002) "The polycomb group protein EZH2 is involved in progression of prostate cancer." Nature 419(6907): 624-629. <http://hdl.handle.net/2027.42/62896> | en_US |
dc.identifier.issn | 0028-0836 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/62896 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=12374981&dopt=citation | en_US |
dc.description.abstract | Prostate cancer is a leading cause of cancer-related death in males and is second only to lung cancer. Although effective surgical and radiation treatments exist for clinically localized prostate cancer, metastatic prostate cancer remains essentially incurable. Here we show, through gene expression profiling(1), that the polycomb group protein enhancer of zeste homolog 2 (EZH2)(2,3) is overexpressed in hormone-refractory, metastatic prostate cancer. Small interfering RNA (siRNA) duplexes(4) targeted against EZH2 reduce the amounts of EZH2 protein present in prostate cells and also inhibit cell proliferation in vitro. Ectopic expression of EZH2 in prostate cells induces transcriptional repression of a specific cohort of genes. Gene silencing mediated by EZH2 requires the SET domain and is attenuated by inhibiting histone deacetylase activity. Amounts of both EZH2 messenger RNA and EZH2 protein are increased in metastatic prostate cancer; in addition, clinically localized prostate cancers that express higher concentrations of EZH2 show a poorer prognosis. Thus, dysregulated expression of EZH2 may be involved in the progression of prostate cancer, as well as being a marker that distinguishes indolent prostate cancer from those at risk of lethal progression. | en_US |
dc.format.extent | 640073 bytes | |
dc.format.extent | 2489 bytes | |
dc.format.mimetype | application/octet-stream | |
dc.format.mimetype | text/plain | |
dc.publisher | Nature Publishing Group | en_US |
dc.source | Nature | en_US |
dc.title | The polycomb group protein EZH2 is involved in progression of prostate cancer | en_US |
dc.type | Article | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA | en_US |
dc.contributor.affiliationum | Univ Michigan, Sch Med, Dept Urol, Ann Arbor, MI 48109 USA | en_US |
dc.contributor.affiliationum | Univ Michigan, Sch Med, Dept Biostat, Ann Arbor, MI 48109 USA | en_US |
dc.contributor.affiliationum | Univ Michigan, Sch Med, Dept Internal Med, Ann Arbor, MI 48109 USA | en_US |
dc.contributor.affiliationum | Univ Michigan, Sch Med, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA | en_US |
dc.contributor.affiliationother | Univ Amsterdam, Biocentrum Amsterdam, Swammerdam Inst Life Sci, NL-1018 TV Amsterdam, Netherlands | en_US |
dc.identifier.pmid | 12374981 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/62896/1/nature01075.pdf | |
dc.identifier.doi | http://dx.doi.org/10.1038/nature01075 | en_US |
dc.identifier.source | Nature | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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