Characterizing the cancer genome in lung adenocarcinoma
dc.contributor.author | Weir, Barbara A. | en_US |
dc.contributor.author | Woo, Michele S. | en_US |
dc.contributor.author | Getz, Gad | en_US |
dc.contributor.author | Perner, Sven | en_US |
dc.contributor.author | Ding, Li | en_US |
dc.contributor.author | Beroukhim, Rameen | en_US |
dc.contributor.author | Lin, William M. | en_US |
dc.contributor.author | Province, Michael A. | en_US |
dc.contributor.author | Kraja, Aldi | en_US |
dc.contributor.author | Johnson, Laura A. | en_US |
dc.contributor.author | Shah, Kinjal | en_US |
dc.contributor.author | Sato, Mitsuo | en_US |
dc.contributor.author | Thomas, Roman K. | en_US |
dc.contributor.author | Barletta, Justine A. | en_US |
dc.contributor.author | Borecki, Ingrid B. | en_US |
dc.contributor.author | Broderick, Stephen | en_US |
dc.contributor.author | Chang, Andrew C. | en_US |
dc.contributor.author | Chiang, Derek Y. | en_US |
dc.contributor.author | Chirieac, Lucian R. | en_US |
dc.contributor.author | Cho, Jeonghee | en_US |
dc.contributor.author | Fujii, Yoshitaka | en_US |
dc.contributor.author | Gazdar, Adi F. | en_US |
dc.contributor.author | Giordano, Thomas J. | en_US |
dc.contributor.author | Greulich, Heidi | en_US |
dc.contributor.author | Hanna, Megan | en_US |
dc.contributor.author | Johnson, Bruce E. | en_US |
dc.contributor.author | Kris, Mark G. | en_US |
dc.contributor.author | Lash, Alex | en_US |
dc.contributor.author | Lin, Ling | en_US |
dc.contributor.author | Lindeman, Neal | en_US |
dc.contributor.author | Mardis, Elaine R. | en_US |
dc.contributor.author | McPherson, John D. | en_US |
dc.contributor.author | Minna, John D. | en_US |
dc.contributor.author | Morgan, Margaret B. | en_US |
dc.contributor.author | Nadel, Mark | en_US |
dc.contributor.author | Orringer, Mark B. | en_US |
dc.contributor.author | Osborne, John R. | en_US |
dc.contributor.author | Ozenberger, Brad | en_US |
dc.contributor.author | Ramos, Alex H. | en_US |
dc.contributor.author | Robinson, James | en_US |
dc.contributor.author | Roth, Jack A. | en_US |
dc.contributor.author | Rusch, Valerie | en_US |
dc.contributor.author | Sasaki, Hidefumi | en_US |
dc.contributor.author | Shepherd, Frances A. | en_US |
dc.contributor.author | Sougnez, Carrie | en_US |
dc.contributor.author | Spitz, Margaret R. | en_US |
dc.contributor.author | Tsao, Ming-Sound | en_US |
dc.contributor.author | Twomey, David | en_US |
dc.contributor.author | Verhaak, Roel G. W. | en_US |
dc.contributor.author | Weinstock, George M. | en_US |
dc.contributor.author | Wheeler, David A. | en_US |
dc.contributor.author | Winckler, Wendy | en_US |
dc.contributor.author | Yoshizawa, Akihiko | en_US |
dc.contributor.author | Yu, Soyoung | en_US |
dc.contributor.author | Zakowski, Maureen F. | en_US |
dc.contributor.author | Zhang, Qunyuan | en_US |
dc.contributor.author | Beer, David G. | en_US |
dc.contributor.author | Wistuba, Ignacio I. | en_US |
dc.contributor.author | Watson, Mark A. | en_US |
dc.contributor.author | Garraway, Levi A. | en_US |
dc.contributor.author | Ladanyi, Marc | en_US |
dc.contributor.author | Travis, William D. | en_US |
dc.contributor.author | Pao, William | en_US |
dc.contributor.author | Rubin, Mark A. | en_US |
dc.contributor.author | Gabriel, Stacey B. | en_US |
dc.contributor.author | Gibbs, Richard A. | en_US |
dc.contributor.author | Varmus, Harold E. | en_US |
dc.contributor.author | Wilson, Richard K. | en_US |
dc.contributor.author | Lander, Eric S. | en_US |
dc.contributor.author | Meyerson, Matthew | en_US |
dc.date.accessioned | 2009-06-01T17:46:00Z | |
dc.date.available | 2009-06-01T17:46:00Z | |
dc.date.issued | 2007-12-06 | en_US |
dc.identifier.citation | Weir, Barbara A.; Woo, Michele S.; Getz, Gad; Perner, Sven; Ding, Li; Beroukhim, Rameen; Lin, William M.; Province, Michael A.; Kraja, Aldi; Johnson, Laura A.; Shah, Kinjal; Sato, Mitsuo; Thomas, Roman K.; Barletta, Justine A.; Borecki, Ingrid B.; Broderick, Stephen; Chang, Andrew C.; Chiang, Derek Y.; Chirieac, Lucian R.; Cho, Jeonghee; Fujii, Yoshitaka; Gazdar, Adi F.; Giordano, Thomas; Greulich, Heidi; Hanna, Megan; Johnson, Bruce E.; Kris, Mark G.; Lash, Alex; Lin, Ling; Lindeman, Neal; Mardis, Elaine R.; McPherson, John D.; Minna, John D.; Morgan, Margaret B.; Nadel, Mark; Orringer, Mark B.; Osborne, John R.; Ozenberger, Brad; Ramos, Alex H.; Robinson, James; Roth, Jack A.; Rusch, Valerie; Sasaki, Hidefumi; Shepherd, Frances; Sougnez, Carrie; Spitz, Margaret R.; Tsao, Ming-Sound; Twomey, David; Verhaak, Roel G. W.; Weinstock, George M.; Wheeler, David A.; Winckler, Wendy; Yoshizawa, Akihiko; Yu, Soyoung; Zakowski, Maureen F.; Zhang, Qunyuan; Beer, David G.; Wistuba, Ignacio I.; Watson, Mark A.; Garraway, Levi A.; Ladanyi, Marc; Travis, William D.; Pao, William; Rubin, Mark A.; Gabriel, Stacey B.; Gibbs, Richard A.; Varmus, Harold E.; Wilson, Richard K.; Lander, Eric S.; Meyerson, Matthew. (2007) "Characterizing the cancer genome in lung adenocarcinoma." Nature 450(7171): 893-U22. <http://hdl.handle.net/2027.42/62944> | en_US |
dc.identifier.issn | 0028-0836 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/62944 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=17982442&dopt=citation | en_US |
dc.description.abstract | Somatic alterations in cellular DNA underlie almost all human cancers(1). The prospect of targeted therapies(2) and the development of high-resolution, genome-wide approaches(3-8) are now spurring systematic efforts to characterize cancer genomes. Here we report a large-scale project to characterize copy-number alterations in primary lung adenocarcinomas. By analysis of a large collection of tumours ( n = 371) using dense single nucleotide polymorphism arrays, we identify a total of 57 significantly recurrent events. We find that 26 of 39 autosomal chromosome arms show consistent large-scale copy-number gain or loss, of which only a handful have been linked to a specific gene. We also identify 31 recurrent focal events, including 24 amplifications and 7 homozygous deletions. Only six of these focal events are currently associated with known mutations in lung carcinomas. The most common event, amplification of chromosome 14q13.3, is found in similar to 12% of samples. On the basis of genomic and functional analyses, we identify NKX2-1 ( NK2 homeobox 1, also called TITF1), which lies in the minimal 14q13.3 amplification interval and encodes a lineage-specific transcription factor, as a novel candidate proto-oncogene involved in a significant fraction of lung adenocarcinomas. More generally, our results indicate that many of the genes that are involved in lung adenocarcinoma remain to be discovered. | en_US |
dc.format.extent | 945095 bytes | |
dc.format.extent | 2489 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Nature Publishing Group | en_US |
dc.source | Nature | en_US |
dc.title | Characterizing the cancer genome in lung adenocarcinoma | en_US |
dc.type | Article | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Univ Michigan, Thorac Surg Sect, Dept Surg, Ann Arbor, MI 48109 USA | en_US |
dc.contributor.affiliationum | Univ Michigan, Dept Pathol, Ann Arbor, MI 48109 USA | en_US |
dc.contributor.affiliationother | Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA | en_US |
dc.contributor.affiliationother | Dana Farber Canc Inst, Ctr Canc Genome Discovery, Boston, MA 02115 USA | en_US |
dc.contributor.affiliationother | Harvard Univ, Canc Program, Broad Inst, Cambridge, MA 02142 USA | en_US |
dc.contributor.affiliationother | Harvard Univ, Genome Biol Program, Broad Inst, Cambridge, MA 02142 USA | en_US |
dc.contributor.affiliationother | MIT, Cambridge, MA 02142 USA | en_US |
dc.contributor.affiliationother | Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA | en_US |
dc.contributor.affiliationother | Univ Ulm, Inst Pathol, D-89081 Ulm, Germany | en_US |
dc.contributor.affiliationother | Washington Univ, Genome Sequencing Ctr, St Louis, MO 63130 USA | en_US |
dc.contributor.affiliationother | Washington Univ, Div Stat Genom, St Louis, MO 63130 USA | en_US |
dc.contributor.affiliationother | Washington Univ, Dept Pathol & Immunol, St Louis, MO 63130 USA | en_US |
dc.contributor.affiliationother | Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA | en_US |
dc.contributor.affiliationother | Univ Cologne, Max Planck Inst Neurol Res, Klaus Joachim Zulch Labs, Max Planck Soc, D-50931 Cologne, Germany | en_US |
dc.contributor.affiliationother | Univ Cologne, Fac Med, D-50931 Cologne, Germany | en_US |
dc.contributor.affiliationother | Univ Cologne, Ctr Integrated Oncol, D-50931 Cologne, Germany | en_US |
dc.contributor.affiliationother | Univ Cologne, Dept Internal Med 1, D-50931 Cologne, Germany | en_US |
dc.contributor.affiliationother | Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA | en_US |
dc.contributor.affiliationother | Mem Sloan Kettering Canc Ctr, Dept Surg, New York, NY 10065 USA | en_US |
dc.contributor.affiliationother | Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10065 USA | en_US |
dc.contributor.affiliationother | Mem Sloan Kettering Canc Ctr, Dept Computat Biol, New York, NY 10065 USA | en_US |
dc.contributor.affiliationother | Mem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10065 USA | en_US |
dc.contributor.affiliationother | Mem Sloan Kettering Canc Ctr, Canc Biol & Genet Program, New York, NY 10065 USA | en_US |
dc.contributor.affiliationother | Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA | en_US |
dc.contributor.affiliationother | Harvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02115 USA | en_US |
dc.contributor.affiliationother | Nagoya City Univ, Sch Med, Dept Surg, Nagoya, Aichi 4678602, Japan | en_US |
dc.contributor.affiliationother | Baylor Coll Med, Human Genome Sequencing Ctr, Houston, TX 77030 USA | en_US |
dc.contributor.affiliationother | NHGRI, NIH, Bethesda, MD 20892 USA | en_US |
dc.contributor.affiliationother | Univ Texas Houston, MD Anderson Canc Ctr, Dept Pathol, Houston, TX 77030 USA | en_US |
dc.contributor.affiliationother | Univ Texas Houston, MD Anderson Canc Ctr, Dept Thorac Head & Neck Med Oncol, Houston, TX 77030 USA | en_US |
dc.contributor.affiliationother | Univ Hlth Network, Toronto, ON M5G 2C4, Canada | en_US |
dc.contributor.affiliationother | Princess Margaret Hosp, Toronto, ON M5G 2C4, Canada | en_US |
dc.contributor.affiliationother | MIT, Dept Biol, Cambridge, MA 02142 USA | en_US |
dc.identifier.pmid | 17982442 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/62944/1/nature06358.pdf | |
dc.identifier.doi | http://dx.doi.org/10.1038/nature06358 | en_US |
dc.identifier.source | Nature | en_US |
dc.contributor.authoremail | matthew_meyerson@dfci.harvard.edu | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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