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Pediatric duodenal cancer and biallelic mismatch repair gene mutations

dc.contributor.authorRoy, Sumitaen_US
dc.contributor.authorRaskin, Leonen_US
dc.contributor.authorRaymond, Victoria M.en_US
dc.contributor.authorThibodeau, Stephen N.en_US
dc.contributor.authorMody, Rajen J.en_US
dc.contributor.authorGruber, Stephen B.en_US
dc.date.accessioned2009-06-01T19:17:02Z
dc.date.available2010-08-02T17:56:56Zen_US
dc.date.issued2009-07-15en_US
dc.identifier.citationRoy, Sumita; Raskin, Leon; Raymond, Victoria M.; Thibodeau, Stephen N.; Mody, Rajen J.; Gruber, Stephen B. (2009). "Pediatric duodenal cancer and biallelic mismatch repair gene mutations." Pediatric Blood & Cancer 53(1): 116-120. <http://hdl.handle.net/2027.42/62997>en_US
dc.identifier.issn1545-5009en_US
dc.identifier.issn1545-5017en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/62997
dc.description.abstractGastrointestinal malignancies are extremely rare in the pediatric population, and duodenal cancers represent an even more unusual entity. Intestinal cancers in young adults and children have been observed to be associated with functional deficiencies of the mismatch repair (MMR) system causing a cancer-predisposition syndrome. We report the case of a 16-year-old female with duodenal adenocarcinoma and past history of medulloblastoma found to have a novel germline bialleleic truncating mutation (c.[949C>T]+[949C>T]) of the PMS2 gene. Pediatr Blood Cancer 2009;53:116–120. © 2009 Wiley-Liss, Inc.en_US
dc.format.extent144604 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherCancer Research, Oncology and Pathologyen_US
dc.titlePediatric duodenal cancer and biallelic mismatch repair gene mutationsen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPediatricsen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDivision of Pediatric Hematology-Oncology, Dept. of Pediatrics, University of Michigan Health System, Ann Arbor, Michigan ; Department of Pediatrics, Division of Pediatric Hematology-Oncology, University of Michigan Health System, 1500 East Medical Center Drive, L2110 Women's Hospital, Ann Arbor, MI 48109-0238.en_US
dc.contributor.affiliationumDepartment of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartment of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDivision of Pediatric Hematology-Oncology, Dept. of Pediatrics, University of Michigan Health System, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartment of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan ; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan ; Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan ; Department of Pediatrics, Division of Pediatric Hematology-Oncology, University of Michigan Health System, 1500 East Medical Center Drive, L2110 Women's Hospital, Ann Arbor, MI 48109-0238.en_US
dc.contributor.affiliationotherDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesotaen_US
dc.identifier.pmid19283792en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/62997/1/21957_ftp.pdf
dc.identifier.doi10.1002/pbc.21957en_US
dc.identifier.sourcePediatric Blood & Canceren_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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