Sequence variation in the mitochondrial gene cytochrome c oxidase subunit I and prostate cancer in African American men Anna M. Ray and Kimberly A. Zuhlke contributed equally to this work.
dc.contributor.author | Ray, Anna M. | en_US |
dc.contributor.author | Zuhlke, Kimberly A. | en_US |
dc.contributor.author | Levin, Albert M. | en_US |
dc.contributor.author | Douglas, Julie A. | en_US |
dc.contributor.author | Cooney, Kathleen A. | en_US |
dc.contributor.author | Petros, John A. | en_US |
dc.date.accessioned | 2009-06-01T19:17:18Z | |
dc.date.available | 2010-07-06T14:30:31Z | en_US |
dc.date.issued | 2009-06-15 | en_US |
dc.identifier.citation | Ray, Anna M.; Zuhlke, Kimberly A.; Levin, Albert M.; Douglas, Julie A.; Cooney, Kathleen A.; Petros, John A. (2009). "Sequence variation in the mitochondrial gene cytochrome c oxidase subunit I and prostate cancer in African American men Anna M. Ray and Kimberly A. Zuhlke contributed equally to this work. ." The Prostate 69(9): 956-960. <http://hdl.handle.net/2027.42/63000> | en_US |
dc.identifier.issn | 0270-4137 | en_US |
dc.identifier.issn | 1097-0045 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/63000 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=19267350&dopt=citation | en_US |
dc.description.abstract | BACKGROUND Previous studies have found associations between mitochondrial DNA (mtDNA) mutations and several cancer types. Recently, we found that mutations in the mtDNA gene cytochrome c oxidase subunit 1 ( COI ) were both linked to and associated with prostate cancer (PCa) in Caucasian men. Here we examine the association between COI mutations and PCa in African American men. METHODS The entire COI gene was directly sequenced in 132 PCa cases and 135 controls from the Flint Men's Health Study, a community-based sample of African American men with and without PCa. Associations between all variants and PCa were evaluated. RESULTS We identified 102 COI single nucleotide polymorphisms (SNPs), including 15 missense variants. Overall, the presence of one or more COI missense variants was not significantly associated with PCa. Individually, two SNPs (T6221C and T7389C) were significantly associated with prostate cancer ( P < 0.05) and in strong linkage disequilibrium with each other ( r 2 > 0.6). CONCLUSIONS Of the two significantly associated SNPs, one is a synonymous substitution and the other is part of the African-specific mitochondrial haplogroup (L). Additional research will be needed to determine the clinical relevance of these associations in African populations. Prostate 69: 956–960, 2009. © 2009 Wiley-Liss, Inc. | en_US |
dc.format.extent | 77264 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cancer Research, Oncology and Pathology | en_US |
dc.title | Sequence variation in the mitochondrial gene cytochrome c oxidase subunit I and prostate cancer in African American men Anna M. Ray and Kimberly A. Zuhlke contributed equally to this work. | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan ; Department of Urology, University of Michigan Medical School, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationother | The Atlanta VA Medical Center, Decatur, Georgia ; Department of Pathology, Emory University School of Medicine, Atlanta, Georgia ; Department of Urology, Emory University School of Medicine, Atlanta, Georgia ; 1365 Clifton Road, Clinic B, Atlanta, GA 30041. | en_US |
dc.identifier.pmid | 19267350 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/63000/1/20943_ftp.pdf | |
dc.identifier.doi | 10.1002/pros.20943 | en_US |
dc.identifier.source | The Prostate | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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