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A New Cationic Liposome DNA Complex Enhances the Efficiency of Arterial Gene Transfer In Vivo

dc.contributor.authorStephan, Dominique J.en_US
dc.contributor.authorYang, Zhi-Yongen_US
dc.contributor.authorSan, Hongen_US
dc.contributor.authorSimari, Robert D.en_US
dc.contributor.authorWheeler, Carl J.en_US
dc.contributor.authorFelgner, Philip L.en_US
dc.contributor.authorGordon, Daviden_US
dc.contributor.authorNabel, Gary J.en_US
dc.contributor.authorNabel, Elizabeth G.en_US
dc.date.accessioned2009-07-10T18:57:05Z
dc.date.available2009-07-10T18:57:05Z
dc.date.issued1996-10-01en_US
dc.identifier.citationStephan, Dominique J.; Yang, Zhi-Yong; San, Hong; Simari, Robert D.; Wheeler, Carl J.; Felgner, Philip L.; Gordon, David; Nabel, Gary J.; Nabel, Elizabeth G. (1996). "A New Cationic Liposome DNA Complex Enhances the Efficiency of Arterial Gene Transfer In Vivo." Human Gene Therapy 7(15): 1803-1812 <http://hdl.handle.net/2027.42/63105>en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/63105
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8894672&dopt=citationen_US
dc.description.abstractOverview summary GAP-DLRIE/DOPE, a new cationic liposome preparation, is an efficient liposomal vector that increases gene expression in arteries compared to naked DNA or previously described cationic DNA–liposome complexes by more than 15-fold. Although less efficient than adenoviral gene transfer, these levels of gene expression represent a significant improvement in liposome transfection in vivo and approach levels observed with clinically acceptable doses of adenoviral vectors. The improvement in gene expression, together with the relative safety associated with liposomal gene transfer, suggests that such nonviral vectors may be appropriate for human gene therapy protocols which utilize catheter-based gene delivery.en_US
dc.format.extent1002574 bytes
dc.format.extent2489 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherMary Ann Liebert, Inc., publishersen_US
dc.titleA New Cationic Liposome DNA Complex Enhances the Efficiency of Arterial Gene Transfer In Vivoen_US
dc.typeArticleen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.identifier.pmid8894672en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/63105/1/hum.1996.7.15-1803.pdf
dc.identifier.doidoi:10.1089/hum.1996.7.15-1803en_US
dc.identifier.sourceHuman Gene Therapyen_US
dc.identifier.sourceHuman Gene Therapyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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