A New Cationic Liposome DNA Complex Enhances the Efficiency of Arterial Gene Transfer In Vivo
dc.contributor.author | Stephan, Dominique J. | en_US |
dc.contributor.author | Yang, Zhi-Yong | en_US |
dc.contributor.author | San, Hong | en_US |
dc.contributor.author | Simari, Robert D. | en_US |
dc.contributor.author | Wheeler, Carl J. | en_US |
dc.contributor.author | Felgner, Philip L. | en_US |
dc.contributor.author | Gordon, David | en_US |
dc.contributor.author | Nabel, Gary J. | en_US |
dc.contributor.author | Nabel, Elizabeth G. | en_US |
dc.date.accessioned | 2009-07-10T18:57:05Z | |
dc.date.available | 2009-07-10T18:57:05Z | |
dc.date.issued | 1996-10-01 | en_US |
dc.identifier.citation | Stephan, Dominique J.; Yang, Zhi-Yong; San, Hong; Simari, Robert D.; Wheeler, Carl J.; Felgner, Philip L.; Gordon, David; Nabel, Gary J.; Nabel, Elizabeth G. (1996). "A New Cationic Liposome DNA Complex Enhances the Efficiency of Arterial Gene Transfer In Vivo." Human Gene Therapy 7(15): 1803-1812 <http://hdl.handle.net/2027.42/63105> | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/63105 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8894672&dopt=citation | en_US |
dc.description.abstract | Overview summary GAP-DLRIE/DOPE, a new cationic liposome preparation, is an efficient liposomal vector that increases gene expression in arteries compared to naked DNA or previously described cationic DNA–liposome complexes by more than 15-fold. Although less efficient than adenoviral gene transfer, these levels of gene expression represent a significant improvement in liposome transfection in vivo and approach levels observed with clinically acceptable doses of adenoviral vectors. The improvement in gene expression, together with the relative safety associated with liposomal gene transfer, suggests that such nonviral vectors may be appropriate for human gene therapy protocols which utilize catheter-based gene delivery. | en_US |
dc.format.extent | 1002574 bytes | |
dc.format.extent | 2489 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Mary Ann Liebert, Inc., publishers | en_US |
dc.title | A New Cationic Liposome DNA Complex Enhances the Efficiency of Arterial Gene Transfer In Vivo | en_US |
dc.type | Article | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.identifier.pmid | 8894672 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/63105/1/hum.1996.7.15-1803.pdf | |
dc.identifier.doi | doi:10.1089/hum.1996.7.15-1803 | en_US |
dc.identifier.source | Human Gene Therapy | en_US |
dc.identifier.source | Human Gene Therapy | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.