Inhibition of Interleukin-1-Induced Effects in Synoviocytes Transduced with the Human IL-1 Receptor Antagonist cDNA Using an Adenoviral Vector
dc.contributor.author | Roessler, Blake J. | en_US |
dc.contributor.author | Hartman, John W. | en_US |
dc.contributor.author | Vallance, David K. | en_US |
dc.contributor.author | Latta, Jill M. | en_US |
dc.contributor.author | Janich, Sonia L. | en_US |
dc.contributor.author | Davidson, Beverly L. | en_US |
dc.date.accessioned | 2009-07-10T18:58:09Z | |
dc.date.available | 2009-07-10T18:58:09Z | |
dc.date.issued | 1995-03-01 | en_US |
dc.identifier.citation | Roessler, Blake J.; Hartman, John W.; Vallance, David K.; Latta, Jill M.; Janich, Sonia L.; Davidson, Beverly L. (1995). "Inhibition of Interleukin-1-Induced Effects in Synoviocytes Transduced with the Human IL-1 Receptor Antagonist cDNA Using an Adenoviral Vector." Human Gene Therapy 6(3): 307-316 <http://hdl.handle.net/2027.42/63124> | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/63124 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7779914&dopt=citation | en_US |
dc.description.abstract | Overview summary Adenovirus-mediated gene transfer into the cells of the synovial membrane may provide a means to deliver therapeutically active proteins for the local modification of the immune response in inflammatory arthropathies. In this study, we infected type B human synoviocytes in vitro and rabbit synovial lining membrane in vivo with a recombinant human adenovirus containing the cDNA for the human interleukin-1 receptor antagonist protein (IL-1ra). Expression of human IL-1ra was observed both in the transduced synoviocytes in vitro and in the microenvironment of the transduced rabbit synovial membrane in vivo, and the functional activity of the transgenic IL-1ra was suggested by in vitro inhibition of interleukin-1 (IL-1)-induced prostaglandin E2 (PGE2) production and by in vivo inhibition of IL-1-induced glycosaminoglycan (GAG) degradation. | en_US |
dc.format.extent | 3026416 bytes | |
dc.format.extent | 2489 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Mary Ann Liebert, Inc., publishers | en_US |
dc.title | Inhibition of Interleukin-1-Induced Effects in Synoviocytes Transduced with the Human IL-1 Receptor Antagonist cDNA Using an Adenoviral Vector | en_US |
dc.type | Article | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.identifier.pmid | 7779914 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/63124/1/hum.1995.6.3-307.pdf | |
dc.identifier.doi | doi:10.1089/hum.1995.6.3-307 | en_US |
dc.identifier.source | Human Gene Therapy | en_US |
dc.identifier.source | Human Gene Therapy | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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