IP-10 Mediates Selective Mononuclear Cell Accumulation and Activation in Response to Intrapulmonary Transgenic Expression and During Adenovirus-Induced Pulmonary Inflammation
dc.contributor.author | Zeng, Xianying | en_US |
dc.contributor.author | Moore, Thomas A. | en_US |
dc.contributor.author | Newstead, Michael W. | en_US |
dc.contributor.author | Deng, Jane C. | en_US |
dc.contributor.author | Lukacs, Nicholas W. | en_US |
dc.contributor.author | Standiford, Theodore J. | en_US |
dc.date.accessioned | 2009-07-10T19:05:10Z | |
dc.date.available | 2009-07-10T19:05:10Z | |
dc.date.issued | 2005-02-01 | en_US |
dc.identifier.citation | Zeng, Xianying; Moore, Thomas A.; Newstead, Michael W.; Deng, Jane C.; Lukacs, Nicholas W.; Standiford, Theodore J. (2005). "IP-10 Mediates Selective Mononuclear Cell Accumulation and Activation in Response to Intrapulmonary Transgenic Expression and During Adenovirus-Induced Pulmonary Inflammation." Journal of Interferon & Cytokine Research 25(2): 103-112 <http://hdl.handle.net/2027.42/63249> | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/63249 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=15695931&dopt=citation | en_US |
dc.description.abstract | CXC chemokines that lack the glutamine-leucine-arginine (ELR) motif, including interferon (IFN)-inducible protein 10 (IP-10 or CXCL10), have been shown to mediate the generation of type 1 immune responses. In this study, we found that the intrapulmonary transient transgenic expression of murine IP-10 in mice using adenoviral gene transfer resulted in the early accumulation of neutrophils, natural killer (NK) cells, and NK T cells within the lung, followed by the delayed accumulation of CD4+ T cells. Adenovirus-mediated transgenic expression of IP-10 also resulted in selective activation of mononuclear cells, including γδ-T cells and NK cells, as manifest by CD69 expression or induction of cell-associated IFN-γ. Importantly, the intratracheal (i.t.) administration of a control human type 5 adenovirus also caused significant accumulation of NK, NK T, and CD4+ T cells, which was maximal at 7 days post vector administration and was associated with the induction of IP-10. Neutralization of endogenous IP-10 in animals receiving control adenovirus resulted in decreases in the numbers of NK, CD4+, and CD8+ T cells. These results indicate that IP-10 can direct the accumulation and activation of neutrophils and selected mononuclear cells to the lung and that adenovirusinduced IP-10 contributes to lung inflammatory cell recruitment/activation observed in response to adenoviral vectors used for gene therapy. | en_US |
dc.format.extent | 237451 bytes | |
dc.format.extent | 2489 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Mary Ann Liebert, Inc., publishers | en_US |
dc.title | IP-10 Mediates Selective Mononuclear Cell Accumulation and Activation in Response to Intrapulmonary Transgenic Expression and During Adenovirus-Induced Pulmonary Inflammation | en_US |
dc.type | Article | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.identifier.pmid | 15695931 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/63249/1/jir.2005.25.103.pdf | |
dc.identifier.doi | doi:10.1089/jir.2005.25.103 | en_US |
dc.identifier.source | Journal of Interferon & Cytokine Research | en_US |
dc.identifier.source | Journal of Interferon & Cytokine Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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