A Method of Limited Replication for the Efficient In Vivo Delivery of Adenovirus to Cancer Cells
dc.contributor.author | Han, Jeffrey S. | en_US |
dc.contributor.author | Qian, Dalong | en_US |
dc.contributor.author | Wicha, Max S. | en_US |
dc.contributor.author | Clarke, Michael F. | en_US |
dc.date.accessioned | 2009-07-10T19:06:55Z | |
dc.date.available | 2009-07-10T19:06:55Z | |
dc.date.issued | 1998-05-20 | en_US |
dc.identifier.citation | Han, Jeffrey S.; Qian, Dalong; Wicha, Max S.; Clarke, Michael F. (1998). "A Method of Limited Replication for the Efficient In Vivo Delivery of Adenovirus to Cancer Cells." Human Gene Therapy 9(8): 1209-1216 <http://hdl.handle.net/2027.42/63280> | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/63280 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=9625260&dopt=citation | en_US |
dc.description.abstract | Overview summary Replication-defective viral vectors are limited in their ability to diffuse through tissue. This poses a problem for treating tumors in vivo using gene transfer. This article demonstrates that limited replication of adenovirus leads to greater gene transfer efficiency in vitro and in vivo without introducing additional safety concerns beyond traditional adenovirus administration. This has implications for the improvement of current gene transfer methods for treating cancer. | en_US |
dc.format.extent | 2647119 bytes | |
dc.format.extent | 2489 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Mary Ann Liebert, Inc., publishers | en_US |
dc.title | A Method of Limited Replication for the Efficient In Vivo Delivery of Adenovirus to Cancer Cells | en_US |
dc.type | Article | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.identifier.pmid | 9625260 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/63280/1/hum.1998.9.8-1209.pdf | |
dc.identifier.doi | doi:10.1089/hum.1998.9.8-1209 | en_US |
dc.identifier.source | Human Gene Therapy | en_US |
dc.identifier.source | Human Gene Therapy | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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