The Teleost Retina as a Model for Developmental and Regeneration Biology
dc.contributor.author | Hitchcock, Peter F. | en_US |
dc.contributor.author | Raymond, Pamela A. | en_US |
dc.date.accessioned | 2009-07-10T19:11:48Z | |
dc.date.available | 2009-07-10T19:11:48Z | |
dc.date.issued | 2004-12-01 | en_US |
dc.identifier.citation | Hitchcock, Peter F.; Raymond, Pamela A. (2004). "The Teleost Retina as a Model for Developmental and Regeneration Biology." Zebrafish 1(3): 257-271 <http://hdl.handle.net/2027.42/63365> | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/63365 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=18248236&dopt=citation | en_US |
dc.description.abstract | Retinal development in teleosts can broadly be divided into three epochs. The first is the specification of cellular domains in the larval forebrain that give rise to the retinal primordia and undergo early morphogenetic movements. The second is the neurogenic events within the retina proper—proliferation, cell fate determination, and pattern formation—that establish neuronal identities and form retinal laminae and cellular mosaics. The third, which is unique to teleosts and occurs in the functioning eye, is stretching of the retina and persistent neurogenesis that allows the growth of the retina to keep pace with the growth of the eye and other tissues. The first two events are rapid, complete by about 3 days postfertilization in the zebrafish embryo. The third is life-long and accounts for the bulk of retinal growth and the vast majority of adult retinal neurons. In addition, but clearly related to the retina's developmental history, lesions that kill retinal neurons elicit robust neuronal regeneration that originates from cells intrinsic to the retina. This paper reviews recent studies of retinal development in teleosts, focusing on those that shed light on the genetic and molecular regulation of retinal specification and morphogenesis in the embryo, retinal neurogenesis in larvae and adults, and injury-induced neuronal regeneration. | en_US |
dc.format.extent | 387806 bytes | |
dc.format.extent | 2489 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Mary Ann Liebert, Inc., publishers | en_US |
dc.title | The Teleost Retina as a Model for Developmental and Regeneration Biology | en_US |
dc.type | Article | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.identifier.pmid | 18248236 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/63365/1/zeb.2004.1.257.pdf | |
dc.identifier.doi | doi:10.1089/zeb.2004.1.257 | en_US |
dc.identifier.source | Zebrafish | en_US |
dc.identifier.source | Zebrafish | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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