Detection of HERV-K(HML-2) Viral RNA in Plasma of HIV Type 1-Infected Individuals
dc.contributor.author | Contreras-Galindo, Rafael | en_US |
dc.contributor.author | Kaplan, Mark H. | en_US |
dc.contributor.author | Markovitz, David M. | en_US |
dc.contributor.author | Lorenzo, Eric | en_US |
dc.contributor.author | Yamamura, Yasuhiro | en_US |
dc.date.accessioned | 2009-07-10T19:15:08Z | |
dc.date.available | 2009-07-10T19:15:08Z | |
dc.date.issued | 2006-10-01 | en_US |
dc.identifier.citation | Contreras-Galindo, Rafael; Kaplan, Mark H.; Markovitz, David M.; Lorenzo, Eric; Yamamura, Yasuhiro (2006). "Detection of HERV-K(HML-2) Viral RNA in Plasma of HIV Type 1-Infected Individuals." AIDS Research and Human Retroviruses 22(10): 979-984 <http://hdl.handle.net/2027.42/63424> | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/63424 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=17067267&dopt=citation | en_US |
dc.description.abstract | Approximately 8% of the human genome sequence is composed by human endogenous retroviruses (HERVs), most of which are defective. HERV-K(HML-2) is the youngest and most active family and has maintained some proviruses with intact open reading frames (ORFs) that code for viral proteins that may assemble into viral particles. Many HERV-K(HML-2) sequences are polymorphic in humans (present in some individuals but not in others) and probably many others may be unfixed (not inserted permanently in a specific chromosomal location of the human genome). In the present study HIV-1 and HCV-1-positive plasma samples were screened for the presence of HERV-K(HML-2) RNA in an RT-PCR using HERV-K pol specific primers. HERV-K(HML-2) viral RNA sequences were found almost universally in HIV-1+ plasma samples (95.33%) but were rarely detected in HCV-1 patients (5.2%) or control subjects (7.69%). Other HERV-K(HML-2) viral segments of the RNA genome including gag, prt, and both env regions, surface (su), and transmembrane (tm) were amplified from HERV-K pol-positive plasma of HIV-1 patients. Type 1 and type 2 HERV-K(HML- 2) viral RNA genomes were found to coexist in the same plasma of HIV-1 patients. These results suggest the HERV-K(HML-2) viral particles are induced in HIV-1-infected individuals. | en_US |
dc.format.extent | 170431 bytes | |
dc.format.extent | 2489 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Mary Ann Liebert, Inc., publishers | en_US |
dc.title | Detection of HERV-K(HML-2) Viral RNA in Plasma of HIV Type 1-Infected Individuals | en_US |
dc.type | Article | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.identifier.pmid | 17067267 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/63424/1/aid.2006.22.979.pdf | |
dc.identifier.doi | doi:10.1089/aid.2006.22.979 | en_US |
dc.identifier.source | AIDS Research and Human Retroviruses | en_US |
dc.identifier.source | AIDS Research and Human Retroviruses | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.