Getting to the crux of the matter: IL-23 and Th17 cell accumulation in the CNS
dc.contributor.author | Segal, Benjamin M. | en_US |
dc.date.accessioned | 2009-08-12T15:35:51Z | |
dc.date.available | 2010-09-01T19:24:06Z | en_US |
dc.date.issued | 2009-07 | en_US |
dc.identifier.citation | Segal, Benjamin M. (2009). "Getting to the crux of the matter: IL-23 and Th17 cell accumulation in the CNS." European Journal of Immunology 39(7): 1713-1715. <http://hdl.handle.net/2027.42/63552> | en_US |
dc.identifier.issn | 0014-2980 | en_US |
dc.identifier.issn | 1521-4141 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/63552 | |
dc.description.abstract | IL-23 plays a critical role in EAE induced by the active immunization of C57BL/6 mice with an immunodominant epitope of myelin oligodendrocyte glycoprotein (MOG 35–55 ). It was initially assumed that the pathogenic effects of IL-23 were directly related to the generation, expansion and/or stabilization of autoreactive CD4 + Th17 cells. However, a number of recent studies have uncovered discrepancies between the requirement for IL-23, as opposed to Th17 cells or their products (IL-17A, IL-17F and IL-22), in the development of EAE. In this issue of the European Journal of Immunology , it is demonstrated that impairment of IL-23 signaling does not impede the expansion of myelin-specific CD4 + T cells in peripheral lymphoid tissues but inhibits their accumulation in the CNS. This paper contributes to a growing body of data that implicates IL-23 in the acquisition of CNS homing properties by autoreactive effector cells. | en_US |
dc.format.extent | 90160 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | WILEY-VCH Verlag | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Microbiology and Immunology | en_US |
dc.title | Getting to the crux of the matter: IL-23 and Th17 cell accumulation in the CNS | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Holtom-Garrett Program in Neuroimmunology, Department of Neurology, University of Michigan, Ann Arbor, MI, USA ; Holtom-Garrett Program in Neuroimmunology, Department of Neurology, University of Michigan, Ann Arbor Michigan, 4009 BSRB, 109 Zina Pitcher Place, SPC 2200, Ann Arbor, MI 48109, USA Fax: +1-734-615-7300 | en_US |
dc.identifier.pmid | 19582738 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/63552/1/1713_ftp.pdf | |
dc.identifier.doi | 10.1002/eji.200939675 | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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