CD24 polymorphisms affect risk and progression of chronic hepatitis B virus infection Potential conflict of interest: The sponsors had no role in the experimental design, data collection, or interpretation.
dc.contributor.author | Li, Dongling | en_US |
dc.contributor.author | Zheng, Linghua | en_US |
dc.contributor.author | Jin, Lei | en_US |
dc.contributor.author | Zhou, Yuesu | en_US |
dc.contributor.author | Li, Haiying | en_US |
dc.contributor.author | Fu, Junliang | en_US |
dc.contributor.author | Shi, Ming | en_US |
dc.contributor.author | Du, Peishuang | en_US |
dc.contributor.author | Wang, Lizhong | en_US |
dc.contributor.author | Wu, Hao | en_US |
dc.contributor.author | Chen, Guo-Yun | en_US |
dc.contributor.author | Zheng, Pan | en_US |
dc.contributor.author | Liu, Yang | en_US |
dc.contributor.author | Wang, Fu-Sheng | en_US |
dc.contributor.author | Wang, Shengdian | en_US |
dc.date.accessioned | 2009-09-02T14:39:15Z | |
dc.date.available | 2010-10-05T18:27:29Z | en_US |
dc.date.issued | 2009-09 | en_US |
dc.identifier.citation | Li, Dongling; Zheng, Linghua; Jin, Lei; Zhou, Yuesu; Li, Haiying; Fu, Junliang; Shi, Ming; Du, Peishuang; Wang, Lizhong; Wu, Hao; Chen, Guo-Yun; Zheng, Pan; Liu, Yang; Wang, Fu-Sheng; Wang, Shengdian (2009). "CD24 polymorphisms affect risk and progression of chronic hepatitis B virus infection Potential conflict of interest: The sponsors had no role in the experimental design, data collection, or interpretation. ." Hepatology 50(3): 735-742. <http://hdl.handle.net/2027.42/63609> | en_US |
dc.identifier.issn | 0270-9139 | en_US |
dc.identifier.issn | 1527-3350 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/63609 | |
dc.description.abstract | T-cell immunity to hepatitis B virus (HBV) is involved in both viral clearance and the pathogenesis of cirrhosis and hepatocellular carcinoma following chronic HBV infection. It is therefore of great interest to analyze whether genetic polymorphism of genes involved in the immune response may determine the outcomes of chronic HBV infection. Here we report that CD24 polymorphisms affect the risk and progression of chronic HBV infection. Thus the CD24 P170 T allele, which is expressed at a higher level, is associated with an increased risk of chronic HBV infection. Among the chronic HBV patients this allele shows recessive association with more rapid progression to liver cirrhosis and hepatocellular carcinoma in comparison to the P170 C allele. In contrast, a dinucleotide deletion at position 1527–1528 (P1527 del ), which reduces CD24 expression, is associated with a significantly reduced risk of chronic HBV infection. To confirm the role for CD24 in liver carcinogenesis, we compared the size of liver tumor developed in CD24 −/− and CD24 +/− HBV transgenic mice. Our data demonstrate that targeted mutation of CD24 drastically reduced the sizes of spontaneous liver cancer in the HBV transgenic mice. Conclusion: These data demonstrate that genetic variation of CD24 may be an important determinant for the outcome of chronic HBV infection. (H EPATOLOGY 2009.) | en_US |
dc.format.extent | 1412915 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Hepatology | en_US |
dc.title | CD24 polymorphisms affect risk and progression of chronic hepatitis B virus infection Potential conflict of interest: The sponsors had no role in the experimental design, data collection, or interpretation. | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Division of Immunotherapy, University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Division of Immunotherapy, University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Division of Immunotherapy, University of Michigan, Ann Arbor, MI ; Department of Surgery, Comprehensive Cancer Center and Program of Molecular Mechanisms of Disease, University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Center for Infection and Immunity, National Laboratory of Biomacromolecules, Institute of Biophysics, Beijing, China ; Division of Immunotherapy, University of Michigan, Ann Arbor, MI ; fax: 734-763-2162. ; 107 Zina Pitcher Place, Ann Arbor, MI 48109 | en_US |
dc.contributor.affiliationother | Center for Infection and Immunity, National Laboratory of Biomacromolecules, Institute of Biophysics, Beijing, China ; These authors contributed equally to this work. | en_US |
dc.contributor.affiliationother | Center for Infection and Immunity, National Laboratory of Biomacromolecules, Institute of Biophysics, Beijing, China ; Graduate School of Chinese Academy of Sciences, China Chinese Academy of Sciences, Beijing, China | en_US |
dc.contributor.affiliationother | Research Center for Biological Therapy, Beijing 302 Hospital, Beijing, China | en_US |
dc.contributor.affiliationother | Research Center for Biological Therapy, Beijing 302 Hospital, Beijing, China | en_US |
dc.contributor.affiliationother | Beijing You-An Hospital, Capital Medical University, Beijing, China | en_US |
dc.contributor.affiliationother | Research Center for Biological Therapy, Beijing 302 Hospital, Beijing, China | en_US |
dc.contributor.affiliationother | Research Center for Biological Therapy, Beijing 302 Hospital, Beijing, China | en_US |
dc.contributor.affiliationother | Center for Infection and Immunity, National Laboratory of Biomacromolecules, Institute of Biophysics, Beijing, China | en_US |
dc.contributor.affiliationother | Beijing You-An Hospital, Capital Medical University, Beijing, China | en_US |
dc.contributor.affiliationother | Center for Infection and Immunity, National Laboratory of Biomacromolecules, Institute of Biophysics, Beijing, China ; Research Center for Biological Therapy, Beijing 302 Hospital, Beijing, China ; 107 Zina Pitcher Place, Ann Arbor, MI 48109 | en_US |
dc.contributor.affiliationother | Center for Infection and Immunity, National Laboratory of Biomacromolecules, Institute of Biophysics, Beijing, China ; 107 Zina Pitcher Place, Ann Arbor, MI 48109 | en_US |
dc.identifier.pmid | 19610054 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/63609/1/23047_ftp.pdf | |
dc.identifier.doi | 10.1002/hep.23047 | en_US |
dc.identifier.source | Hepatology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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