Noninvasive model of sciatic nerve conduction in healthy and septic mice: Reliability and normative data
dc.contributor.author | Osuchowski, Marcin F. | en_US |
dc.contributor.author | Teener, James | en_US |
dc.contributor.author | Remick, Daniel G. | en_US |
dc.date.accessioned | 2009-10-02T16:55:33Z | |
dc.date.available | 2010-12-01T21:34:38Z | en_US |
dc.date.issued | 2009-10 | en_US |
dc.identifier.citation | Osuchowski, Marcin F.; Teener, James; Remick, Daniel (2009). "Noninvasive model of sciatic nerve conduction in healthy and septic mice: Reliability and normative data." Muscle & Nerve 40(4): 610-616. <http://hdl.handle.net/2027.42/64096> | en_US |
dc.identifier.issn | 0148-639X | en_US |
dc.identifier.issn | 1097-4598 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/64096 | |
dc.description.abstract | Neuromuscular disorders frequently complicate sepsis and other critical illnesses in patients. Mice are the major species used as a model for sepsis. Nerve conduction studies (NCS), the primary tool for noninvasive assessment of nerve and muscle function, is challenging to perform in small animals. A reliable method for noninvasive, repeated NCS testing has not been reported in mice. We developed and validated a method for the repeated measurement of mouse sciatic nerve conduction in normal and septic mice. Our sedated and awake NCS system enabled minimally invasive long-term repeated measurements. The mean compound muscle action potential (CMAP) amplitude and latency were 17.4 mV and 1.11 ms, respectively ( n = 59). There was an excellent intertester reproducibility by linear regression in both normal ( r = 0.95) and septic ( r = 0.98) mice. We also showed significant, time-dependent isoflurane-induced CMAP suppression in all animals, which was further exacerbated in septic mice. This study provides a new tool for the assessment of peripheral nerve/muscle function in mouse neuromuscular disease models that require repeated, long-term, and minimally invasive monitoring. Muscle Nerve, 2009 | en_US |
dc.format.extent | 314556 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Neuroscience, Neurology and Psychiatry | en_US |
dc.title | Noninvasive model of sciatic nerve conduction in healthy and septic mice: Reliability and normative data | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Neurology, University of Michigan Medical School, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationother | Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, Massachusetts, USA ; Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria | en_US |
dc.contributor.affiliationother | Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, Massachusetts, USA ; Department of Pathology and Laboratory Medicine, Boston University School of Medicine; 670 Albany Street, Biosquare III, Boston, MA 02118 | en_US |
dc.identifier.pmid | 19618431 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/64096/1/21284_ftp.pdf | |
dc.identifier.doi | 10.1002/mus.21284 | en_US |
dc.identifier.source | Muscle & Nerve | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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