Metal ion-mediated nitric oxide generation from polyurethanes via covalently linked copper(II)-cyclen moieties
dc.contributor.author | Puiu, Simona C. | en_US |
dc.contributor.author | Zhou, Zhengrong | en_US |
dc.contributor.author | White, Cortney C. | en_US |
dc.contributor.author | Neubauer, Laura J. | en_US |
dc.contributor.author | Zhang, Zhenfang | en_US |
dc.contributor.author | Lange, Laura E. | en_US |
dc.contributor.author | Mansfield, Joel A. | en_US |
dc.contributor.author | Meyerhoff, Mark E. | en_US |
dc.contributor.author | Reynolds, Melissa M. | en_US |
dc.date.accessioned | 2009-10-02T16:57:17Z | |
dc.date.available | 2010-12-01T21:34:38Z | en_US |
dc.date.issued | 2009-10 | en_US |
dc.identifier.citation | Puiu, Simona C.; Zhou, Zhengrong; White, Cortney C.; Neubauer, Laura J.; Zhang, Zhenfang; Lange, Laura E.; Mansfield, Joel A.; Meyerhoff, Mark E.; Reynolds, Melissa M. (2009). "Metal ion-mediated nitric oxide generation from polyurethanes via covalently linked copper(II)-cyclen moieties." Journal of Biomedical Materials Research Part B: Applied Biomaterials 91B(1): 203-212. <http://hdl.handle.net/2027.42/64117> | en_US |
dc.identifier.issn | 1552-4973 | en_US |
dc.identifier.issn | 1552-4981 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/64117 | |
dc.description.abstract | Polyurethanes are widely used in the manufacturing of biomedical catheters and other blood-contacting devices; however, thrombus formation still occurs, which renders these catheters ineffective unless systemic anticlotting agents are used. Nitric oxide (NO) is a well-known inhibitor of platelet activity. In the current study, two commercially available medical polyurethanes (Pellethane™ and Tecophilic®) were derivatized to possess NO-generating Cu(II)-cyclen moieties pendant to the polymer backbone. A new three-step synthetic approach is used, that is simpler than a recently reported method to prepare Cu(II)-cyclen-polyurethane materials. Both derivatized polyurethanes were found to produce NO at levels at or above those of endothelial cells. A comparison between the modified commercial polyurethanes (hydrophobic vs. hydrophilic) is presented, including the synthetic scheme, extensive characterization, and coating application. These derivatized polymers may serve as useful coatings to prevent clotting on the surface of catheters and other blood-contacting biomedical devices. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2009 | en_US |
dc.format.extent | 282442 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Chemistry | en_US |
dc.subject.other | Polymer and Materials Science | en_US |
dc.title | Metal ion-mediated nitric oxide generation from polyurethanes via covalently linked copper(II)-cyclen moieties | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Biomedical Engineering | en_US |
dc.subject.hlbsecondlevel | Materials Science and Engineering | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | MC3, Inc, Ann Arbor, Michigan ; Department of Chemistry, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Chemistry, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationother | MC3, Inc, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationother | MC3, Inc, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationother | MC3, Inc, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationother | MC3, Inc, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationother | MC3, Inc, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationother | MC3, Inc, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationother | MC3, Inc, Ann Arbor, Michigan ; MC3, Inc, Ann Arbor, Michigan | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/64117/1/31391_ftp.pdf | |
dc.identifier.doi | 10.1002/jbm.b.31391 | en_US |
dc.identifier.source | Journal of Biomedical Materials Research Part B: Applied Biomaterials | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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