Vinflunine in platinum-pretreated patients with locally advanced or metastatic urothelial carcinoma
dc.contributor.author | Vaughn, David J. | en_US |
dc.contributor.author | Srinivas, Sandy | en_US |
dc.contributor.author | Stadler, Walter M. | en_US |
dc.contributor.author | Pili, Roberto | en_US |
dc.contributor.author | Petrylak, Daniel | en_US |
dc.contributor.author | Sternberg, Cora N. | en_US |
dc.contributor.author | Smith, David C. | en_US |
dc.contributor.author | Ringuette, Sarah | en_US |
dc.contributor.author | de Wit, Edwin | en_US |
dc.contributor.author | Pautret, Virginie | en_US |
dc.contributor.author | George, Claude | en_US |
dc.date.accessioned | 2009-10-02T16:57:22Z | |
dc.date.available | 2010-10-05T18:27:29Z | en_US |
dc.date.issued | 2009-09-15 | en_US |
dc.identifier.citation | Vaughn, David J.; Srinivas, Sandy; Stadler, Walter M.; Pili, Roberto; Petrylak, Daniel; Sternberg, Cora N.; Smith, David C.; Ringuette, Sarah; de Wit, Edwin; Pautret, Virginie; George, Claude (2009). "Vinflunine in platinum-pretreated patients with locally advanced or metastatic urothelial carcinoma Presented in part at the 14th European Cancer Conference, Barcelona, Spain, September 23-27, 2007; and the American Society of Clinical Oncology Genitourinary Cancers Symposium, San Francisco, California, February 14-16, 2008. ." Cancer 115(18): 4110-4117. <http://hdl.handle.net/2027.42/64118> | en_US |
dc.identifier.issn | 0008-543X | en_US |
dc.identifier.issn | 1097-0142 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/64118 | |
dc.description.abstract | BACKGROUND: The activity and safety of vinflunine was evaluated in patients with locally advanced or metastatic urothelial carcinoma (UC) who developed disease progression within 12 months of platinum-containing chemotherapy. METHODS: Patients with UC were eligible if they received a prior platinum-based regimen in the neoadjuvant/adjuvant setting or as first-line treatment for advanced/metastatic disease and had developed disease progression within 12 months. Vinflunine was administered intravenously every 3 weeks. Patients with Karnofsky performance status of 80 or 90, impaired renal function, prior pelvic irradiation, or age ≥75 years received an initial dose of 280 mg/m 2 , which was escalated to 320 mg/m 2 in Cycle 2 if well tolerated. All other patients received an initial dose of 320 mg/m 2 . The primary endpoint was response rate defined by an independent response review committee (IRRC). RESULTS: Per the IRRC, 22 patients achieved a partial response, with a response rate of 15% (95% confidence interval, 9%-21%) with a median duration of response of 6.0 months. Sixty-four (42%) patients had stable disease. The median progression-free survival was 2.8 months, and the median overall survival was 8.2 months. Myelosuppression was the most frequent adverse event, with grade 3 of 4 (adverse events were evaluated according to the National Cancer Institute Common Toxicity Criteria [version 2.0] guidelines) neutropenia reported in 58% of the patients. Grade 3 of 4 febrile neutropenia occurred in 10 (7%) patients. Nonhematologic treatment-related events (grade 3 of 4) were generally manageable and included constipation (17%), asthenia/fatigue (13%), ileus (5%), and abdominal pain (5%). No cumulative toxicity was observed. CONCLUSIONS: Vinflunine demonstrates moderate activity in patients with platinum-pretreated UC. Toxicity is manageable and noncumulative. Cancer 2009. © 2009 American Cancer Society. | en_US |
dc.format.extent | 168440 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cancer Research, Oncology and Pathology | en_US |
dc.title | Vinflunine in platinum-pretreated patients with locally advanced or metastatic urothelial carcinoma | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Oncology and Hematology | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Medicine, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationother | Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania ; Fax: (215) 662-7804 ; Abramson Cancer Center of the University of Pennsylvania, 16 Penn Tower, 300 Spruce Street, Philadelphia, PA 19104 | en_US |
dc.contributor.affiliationother | Department of Medicine, Stanford University, Stanford, California | en_US |
dc.contributor.affiliationother | Department of Medicine, University of Chicago, Chicago, Illinois | en_US |
dc.contributor.affiliationother | Department of Medicine, Johns Hopkins University, Baltimore, Maryland | en_US |
dc.contributor.affiliationother | Department of Medicine, Columbia University, New York, New York | en_US |
dc.contributor.affiliationother | Department of Medicine, San Camillo Forlanini Hospital, Rome, Italy | en_US |
dc.contributor.affiliationother | Bristol-Myers Squibb, Wallingford, Connecticut | en_US |
dc.contributor.affiliationother | Bristol-Myers Squibb, Wallingford, Connecticut | en_US |
dc.contributor.affiliationother | Bristol-Myers Squibb, Braine L'Alleud, Belgium | en_US |
dc.contributor.affiliationother | Bristol-Myers Squibb, Princeton, New Jersey | en_US |
dc.identifier.pmid | 19536904 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/64118/1/24460_ftp.pdf | |
dc.identifier.doi | 10.1002/cncr.24460 | en_US |
dc.identifier.source | Cancer | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.