Liver transplantation outcomes among Caucasians, Asian Americans, and African Americans with hepatitis B
dc.contributor.author | Bzowej, Natalie | en_US |
dc.contributor.author | Han, Steven-Huy B. | en_US |
dc.contributor.author | Degertekin, Bulent | en_US |
dc.contributor.author | Keeffe, Emmet B. | en_US |
dc.contributor.author | Emre, Sukru | en_US |
dc.contributor.author | Brown, Robert | en_US |
dc.contributor.author | Reddy, Rajender K. | en_US |
dc.contributor.author | Lok, Anna Suk-Fong | en_US |
dc.date.accessioned | 2009-10-02T16:57:42Z | |
dc.date.available | 2010-10-05T18:27:29Z | en_US |
dc.date.issued | 2009-09 | en_US |
dc.identifier.citation | Bzowej, Natalie; Han, Steven; Degertekin, Bulent; Keeffe, Emmet B.; Emre, Sukru; Brown, Robert; Reddy, Rajender; Lok, Anna S. (2009). "Liver transplantation outcomes among Caucasians, Asian Americans, and African Americans with hepatitis B See Editorial on Page 1007 Roche Molecular Diagnostics provided Amplicor kits for the hepatitis B virus DNA assays. ." Liver Transplantation 15(9): 1010-1020. <http://hdl.handle.net/2027.42/64122> | en_US |
dc.identifier.issn | 1527-6465 | en_US |
dc.identifier.issn | 1527-6473 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/64122 | |
dc.description.abstract | Several previous studies found that Asians transplanted for hepatitis B virus (HBV) infection had worse post-transplant outcomes than Caucasians. Data on post-transplant outcomes of African Americans and waitlist outcomes of Asian Americans and African Americans with hepatitis B are scant. The aim of this study was to compare waitlist and post-transplant outcomes among Asian Americans, African Americans, and Caucasians who had HBV-related liver disease. Data from a retrospective-prospective study on liver transplantation for HBV infection were analyzed. A total of 274 patients (116 Caucasians, 135 Asians, and 23 African Americans) from 15 centers in the United States were enrolled. African Americans were younger and more Asian Americans had hepatocellular carcinoma (HCC) at the time of liver transplant listing. The probability of undergoing transplantation and the probability of survival on the waitlist were comparable in the 3 racial groups. Of the 170 patients transplanted, 19 died during a median follow-up of 31 months. The probability of post-transplant survival at 5 years was 94% for African Americans, 85% for Asian Americans, and 89% for Caucasians ( P = 0.93). HCC recurrence was the only predictor of post-transplant survival, and recurrence rates were similar in the 3 racial groups. Caucasians had a higher rate of HBV recurrence: 4-year recurrence was 19% versus 7% and 6% for Asian Americans and African Americans, respectively ( P = 0.043). In conclusion, we found similar waitlist and post-transplant outcomes among Caucasians, Asian Americans, and African Americans with hepatitis B. Our finding of a higher rate of HBV recurrence among Caucasians needs to be validated in other studies. Liver Transpl 15:1010–1020, 2009. © 2009 AASLD. | en_US |
dc.format.extent | 265235 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Surgery | en_US |
dc.title | Liver transplantation outcomes among Caucasians, Asian Americans, and African Americans with hepatitis B | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Surgery and Anesthesiology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | California Pacific Medical Center, San Francisco, CA ; University of California, Los Angeles, CA ; Division of Gastroenterology, University of Michigan Health System, Ann Arbor, MI ; Division of Gastroenterology and Hepatology, Stanford University Medical Center, Stanford, CA ; Mount Sinai Medical Center, New York, NY ; Center for Liver Disease and Transplantation, Columbia University College of Physicians and Surgeons, New York, NY ; University of Pennsylvania, Philadelphia, PA | en_US |
dc.contributor.affiliationum | Division of Gastroenterology, University of Michigan Health System, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Mount Sinai Medical Center, New York, NY | en_US |
dc.contributor.affiliationum | Division of Gastroenterology, University of Michigan Health System, Ann Arbor, MI ; Telephone: 734-936-7511; FAX: 734-936-7024 ; Division of Gastroenterology, University of Michigan Medical Center, 3912 Taubman Center, SPC 5362, Ann Arbor, MI 48109 | en_US |
dc.contributor.affiliationother | University of California, Los Angeles, CA | en_US |
dc.contributor.affiliationother | Division of Gastroenterology and Hepatology, Stanford University Medical Center, Stanford, CA | en_US |
dc.contributor.affiliationother | Center for Liver Disease and Transplantation, Columbia University College of Physicians and Surgeons, New York, NY | en_US |
dc.contributor.affiliationother | University of Pennsylvania, Philadelphia, PA | en_US |
dc.identifier.pmid | 19718627 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/64122/1/21759_ftp.pdf | |
dc.identifier.doi | 10.1002/lt.21759 | en_US |
dc.identifier.source | Liver Transplantation | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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