Knee osteoarthritis in obese women with cardiometabolic clustering
dc.contributor.author | Sowers, MaryFran R. | en_US |
dc.contributor.author | Karvonen-Gutierrez, Carrie A. | en_US |
dc.contributor.author | Palmieri-Smith, Riann M. | en_US |
dc.contributor.author | Jacobson, Jon A. | en_US |
dc.contributor.author | Jiang, Yebin | en_US |
dc.contributor.author | Ashton-Miller, James A. | en_US |
dc.date.accessioned | 2009-11-06T16:48:54Z | |
dc.date.available | 2010-03-01T21:10:29Z | en_US |
dc.date.issued | 2009-10-15 | en_US |
dc.identifier.citation | Sowers, Maryfran; Karvonen-Gutierrez, Carrie A.; Palmieri-Smith, Riann; Jacobson, Jon A.; Jiang, Yebin; Ashton-Miller, James A. (2009). "Knee osteoarthritis in obese women with cardiometabolic clustering." Arthritis & Rheumatism 61(10): 1328-1336. <http://hdl.handle.net/2027.42/64312> | en_US |
dc.identifier.issn | 0004-3591 | en_US |
dc.identifier.issn | 1529-0131 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/64312 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=19790111&dopt=citation | en_US |
dc.description.abstract | Objective To assess the role of obesity and metabolic dysfunctionality with knee osteoarthritis (OA), knee joint pain, and physical functioning performance, adjusted for joint space width (JSW) asymmetry. Methods Knee OA was defined as a Kellgren/Lawrence score ≥2 on weight-bearing radiographs. Obesity was defined as a body mass index ≥30 kg/m 2 . Cardiometabolic clustering classification was based on having ≥2 of the following factors: low levels of high-density lipoprotein cholesterol; elevated levels of low-density lipoprotein cholesterol, triglycerides, blood pressure, C-reactive protein, waist:hip ratio, or glucose; or diabetes mellitus. The difference between lateral and medial knee JSW was used to determine joint space asymmetry. Results In a sample of women (n = 482, mean age 47 years), prevalences of knee OA and persistent knee pain were 11% and 30%, respectively. The knee OA prevalence in nonobese women without cardiometabolic clustering was 4.7%, compared with 12.8% in obese women without cardiometabolic clustering and 23.2% in obese women with cardiometabolic clustering. Nonobese women without cardiometabolic clustering were less likely to perceive themselves as limited compared with women in all other obesity/cardiometabolic groups ( P < 0.05). Similar associations were seen with knee pain and physical functioning measures. The inclusion of a joint space asymmetry measure was associated with knee OA but not with knee pain or physical functioning. Conclusion Knee OA was twice as frequent in obese women with cardiometabolic clustering compared with those without, even when considering age and joint asymmetry. Obesity/cardiometabolic clustering was also associated with persistent knee pain and impaired physical functioning. | en_US |
dc.format.extent | 104857 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.title | Knee osteoarthritis in obese women with cardiometabolic clustering | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Geriatrics | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | University of Michigan, Ann Arbor ; University of Michigan School of Public Health, Department of Epidemiology, 109 Observatory, Room 1846, Ann Arbor, MI 48109 | en_US |
dc.contributor.affiliationum | University of Michigan, Ann Arbor | en_US |
dc.contributor.affiliationum | University of Michigan, Ann Arbor | en_US |
dc.contributor.affiliationum | University of Michigan, Ann Arbor | en_US |
dc.contributor.affiliationum | University of Michigan, Ann Arbor | en_US |
dc.contributor.affiliationum | University of Michigan, Ann Arbor | en_US |
dc.identifier.pmid | 19790111 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/64312/1/24739_ftp.pdf | |
dc.identifier.doi | 10.1002/art.24739 | en_US |
dc.identifier.source | Arthritis & Rheumatism | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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