Cytology of metastatic renal medullary carcinoma in pleural effusion: A study of two cases
dc.contributor.author | Ellis, Carla L. | en_US |
dc.contributor.author | Burroughs, Frances | en_US |
dc.contributor.author | Michael, Claire W. | en_US |
dc.contributor.author | Li, Qing Kay | en_US |
dc.date.accessioned | 2009-11-06T16:49:58Z | |
dc.date.available | 2010-03-01T21:10:29Z | en_US |
dc.date.issued | 2009-11 | en_US |
dc.identifier.citation | Ellis, Carla L.; Burroughs, Frances; Michael, Claire W.; Li, Qing Kay (2009). "Cytology of metastatic renal medullary carcinoma in pleural effusion: A study of two cases." Diagnostic Cytopathology 37(11): 843-848. <http://hdl.handle.net/2027.42/64325> | en_US |
dc.identifier.issn | 8755-1039 | en_US |
dc.identifier.issn | 1097-0339 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/64325 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=19526572&dopt=citation | en_US |
dc.description.abstract | Renal medullary carcinoma (RMC) is a rare and aggressive malignant epithelial neoplasm of the kidney. It almost exclusively affects children and young adults with a sickle cell trait or sickle cell disease. The majority of RMC patients present with widely disseminated disease at the time of diagnosis. Herein, we report two cases of young African-American patients with history of sickle cell trait, hematuria and renal mass, who present with malignant right pleural effusions. The cytology of pleural effusion reveals predominantly clusters and individual tumor cells. The tumor cells show high nuclear to cytoplasmic (NC) ratios and large nuclei with nuclear pleomorphism, nuclear grooves, and prominent single or multiple nucleoli. The cytoplasm is dense with a vacuolated and two-tone appearance. Surgical specimens of renal mass and lymph node show features of RMC. Metastatic RMC to the serous cavity is rare and may present a diagnostic dilemma since it may mimic a poorly differentiated adenocarcinoma or other high-grade malignant neoplasms. RMC should be considered in the differential diagnosis in young patients with a renal mass, particularly in those with history of sickle cell trait or sickle cell disease. Diagn. Cytopathol. 2009. © 2009 Wiley-Liss, Inc. | en_US |
dc.format.extent | 413554 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cancer Research, Oncology and Pathology | en_US |
dc.title | Cytology of metastatic renal medullary carcinoma in pleural effusion: A study of two cases | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Pathology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pathology, The University of Michigan Hospital, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationother | Division of Cytopathology, Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland | en_US |
dc.contributor.affiliationother | Division of Cytopathology, Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland | en_US |
dc.contributor.affiliationother | Division of Cytopathology, Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland ; Division of Cytopathology, Department of Pathology, The Johns Hopkins Hospital, 600 N. Wolfe Street, Baltimore, MD 21287 | en_US |
dc.identifier.pmid | 19526572 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/64325/1/21111_ftp.pdf | |
dc.identifier.doi | 10.1002/dc.21111 | en_US |
dc.identifier.source | Diagnostic Cytopathology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.