Now showing items 1-10 of 16
Glycogen synthase kinase-3 regulates mouse oocyte homologue segregation
(Wiley Subscription Services, Inc., A Wiley Company, 2003-01)
Intracellular regulation of oocyte meiosis is not completely understood. However, reversible phosphorylation, which involves serine/threonine protein kinases and phosphatases (PP), is an important mediator. Glycogen synthase ...
Glycogen synthase kinase-3 regulation of chromatin segregation and cytokinesis in mouse preimplantation embryos
(Wiley Subscription Services, Inc., A Wiley Company, 2007-02)
Glycogen synthase kinase-3 (GSK-3) is a highly conserved serine/threonine protein kinase implicated in diverse cellular processes. Activity of GSK-3 is essential for meiotic chromatin segregation in oocytes, yet expression ...
Merkel cell carcinoma: Critical review with guidelines for multidisciplinary management
(Wiley Subscription Services, Inc., A Wiley Company, 2007-07-01)
Merkel cell carcinoma (MCC) is a relatively rare cutaneous malignancy that occurs predominantly in the older white population. The incidence of MCC appears to have tripled during the past 20 years; an increase that is ...
The impact of factors beyond Breslow depth on predicting sentinel lymph node positivity in melanoma
(Wiley Subscription Services, Inc., A Wiley Company, 2007-01-01)
BACKGROUND. In addition to Breslow depth, the authors previously described how increasing mitotic rate and decreasing age predicted sentinel lymph node (SLN) metastases in patients with melanoma. The objectives of the ...
Low recurrence rate after surgery for dermatofibrosarcoma protuberans
(Wiley Subscription Services, Inc., A Wiley Company, 2004-03-01)
BACKGROUND Dermatofibrosarcoma protuberans (DFSP) is a rare sarcoma with a propensity for local recurrence. Treatments with wide excision, Mohs surgery, and other approaches have been reported with widely variable local ...
Distribution of co-activators CBP and p300 during mouse oocyte and embryo development
(Wiley Subscription Services, Inc., A Wiley Company, 2006-07)
cAMP response element binding protein (CREB)-binding protein (CBP) and p300 are two structurally related transcriptional co-activators that activate expression of many eukaryotic genes. Current dogma would suggest that ...
Wide excision without radiation for desmoplastic melanoma
(Wiley Subscription Services, Inc., A Wiley Company, 2005-10-01)
BACKGROUND Adjuvant radiation has been proposed for the treatment of patients with desmoplastic melanoma, who reportedly have local recurrence rates as high as 40–60%. The authors investigated local recurrence rates at a ...
Large Fetal Pulmonary Arteriovenous Fistula: Impact on Pulmonary Development
(Springer-Verlag; Springer-Verlag New York Inc., 2002-07)
A case report of a patient with a large pulmonary arteriovenous fistula and valvar pulmonary stenosis is presented. The fistula was diagnosed prenatally and its effect on in utero cardiovascular growth and development ...
Racial differences in cervical cancer survival in the Detroit metropolitan area
(Wiley Subscription Services, Inc., A Wiley Company, 2008-03-15)
BACKGROUND African-American (AA) women have lower survival rates from cervical cancer compared with white women. The objective of this study was to examine the influence of socioeconomic status (SES) and other variables ...
Desmoplastic and neurotropic melanoma
(Wiley Subscription Services, Inc., A Wiley Company, 2004-02-01)
BACKGROUND Desmoplastic and neurotropic melanoma (DNMM) occasionally metastasizes to regional lymph nodes and extranodal sites. The value of sentinel lymph node biopsy (SLNB) has not been demonstrated clearly for patients ...