Epidemiologic features and clinical subgroups of anotia/microtia in Texas
dc.contributor.author | Canfield, Mark A. | en_US |
dc.contributor.author | Langlois, Peter H. | en_US |
dc.contributor.author | Nguyen, Ly M. | en_US |
dc.contributor.author | Scheuerle, Angela E. | en_US |
dc.date.accessioned | 2009-11-30T16:44:37Z | |
dc.date.available | 2010-03-01T21:10:28Z | en_US |
dc.date.issued | 2009-11 | en_US |
dc.identifier.citation | Canfield, Mark A.; Langlois, Peter H.; Nguyen, Ly M.; Scheuerle, Angela E. (2009). "Epidemiologic features and clinical subgroups of anotia/microtia in Texas Results from earlier dataset (1999–2001) were presented as a poster at the Annual Meeting of the National Birth Defects Prevention Network, January 30–February 1, 2006, Arlington, VA. ." Birth Defects Research Part A: Clinical and Molecular Teratology 85(11): 905-913. <http://hdl.handle.net/2027.42/64447> | en_US |
dc.identifier.issn | 1542-0752 | en_US |
dc.identifier.issn | 1542-0760 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/64447 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=19760683&dopt=citation | en_US |
dc.description.abstract | BACKGROUND: Few studies have investigated the epidemiologic features of clinically defined subgroups of anotia/microtia. METHODS: Data on cases of anotia and/or microtia among 1999–2005 deliveries were obtained from the Texas Birth Defects Registry, a population-based active surveillance system. We determined crude and adjusted associations between selected factors and seven clinical subgroups of anotia/microtia. RESULTS: In total, 742 cases were diagnosed with anotia and/or microtia, corresponding to a prevalence of 2.86 per 10,000 live births. Of those, 45% had no other major birth defect (“isolated”), 77% were unilateral, and 22% bilateral. Anotia alone made up 6%, whereas microtia made up 94%. Birth prevalence was higher with increasing maternal age and among Mexico-born Hispanics. Compared to white mothers, Hispanic mothers were two-to-three times more likely to have infants with all but the syndromic and bilateral groups (adjusted prevalence ratios [aPRs] = 2.05–2.61). Non-Hispanic blacks had significantly lower risk for total anotia/microtia, and for the isolated, unilateral, and microtia subgroups (aPRs = 0.42–0.64). Less educated mothers were three-to-four times more likely to have children with anotia (aPRs = 2.98 for less than high school, 3.97 for high school graduates). Males were more likely to be born with total anotia/microtia and with syndromic, unilateral, and microtia subtypes (aPRs = 1.27–1.41). CONCLUSIONS: In Texas, most anotia/microtia cases were in the unilateral and microtia groups, and 45% were isolated. Several clinical subgroups exhibited higher prevalence in males and among older mothers. Relative to whites, blacks were at lower risk and Hispanics (especially Mexico-born mothers) were at higher risk for selected types of anotia/microtia. Birth Defects Research (Part A) 2009. © 2009 Wiley-Liss, Inc. | en_US |
dc.format.extent | 119175 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cell & Developmental Biology | en_US |
dc.title | Epidemiologic features and clinical subgroups of anotia/microtia in Texas | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Pediatrics | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | University of Michigan, Department of Epidemiology, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationother | Texas Birth Defects Epidemiology & Surveillance Branch, Texas Department of State Health Services, Austin, Texas ; Texas Birth Defects Epidemiology & Surveillance Branch, Mailcode 1964, P.O. Box 149347, Austin, TX, 78714-9347 | en_US |
dc.contributor.affiliationother | Texas Birth Defects Epidemiology & Surveillance Branch, Texas Department of State Health Services, Austin, Texas | en_US |
dc.contributor.affiliationother | Texas Birth Defects Epidemiology & Surveillance Branch, Texas Department of State Health Services, Austin, Texas ; Tesserae Genetics, Dallas, Texas | en_US |
dc.identifier.pmid | 19760683 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/64447/1/20626_ftp.pdf | |
dc.identifier.doi | 10.1002/bdra.20626 | en_US |
dc.identifier.source | Birth Defects Research Part A: Clinical and Molecular Teratology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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