Dynamic patterning at the pylorus: Formation of an epithelial intestine–stomach boundary in late fetal life
dc.contributor.author | Li, Xing | en_US |
dc.contributor.author | Udager, Aaron M. | en_US |
dc.contributor.author | Hu, Chunbo | en_US |
dc.contributor.author | Qiao, Xiaotan T. | en_US |
dc.contributor.author | Richards, Neil | en_US |
dc.contributor.author | Gumucio, Deborah L. | en_US |
dc.date.accessioned | 2010-01-05T15:12:02Z | |
dc.date.available | 2010-03-01T21:10:29Z | en_US |
dc.date.issued | 2009-12 | en_US |
dc.identifier.citation | Li, Xing; Udager, Aaron M.; Hu, Chunbo; Qiao, Xiaotan T.; Richards, Neil; Gumucio, Deborah L. (2009). "Dynamic patterning at the pylorus: Formation of an epithelial intestine–stomach boundary in late fetal life." Developmental Dynamics 238(12): 3205-3217. <http://hdl.handle.net/2027.42/64560> | en_US |
dc.identifier.issn | 1058-8388 | en_US |
dc.identifier.issn | 1097-0177 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/64560 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=19877272&dopt=citation | en_US |
dc.description.abstract | In the adult mouse, distinct morphological and transcriptional differences separate stomach from intestinal epithelium. Remarkably, the epithelial boundary between these two organs is literally one cell thick. This discrete junction is established suddenly and precisely at embryonic day (E) 16.5, by sharpening a previously diffuse intermediate zone. In the present study, we define the dynamic transcriptome of stomach, pylorus, and intestinal tissues between E14.5 and E16.5. We show that establishment of this boundary is concomitant with the induction of over a thousand genes in intestinal epithelium, and these gene products provide intestinal character. Hence, we call this process intestinalization . We identify specific transcription factors (Hnf4Γ, Creb3l3, and Tcfec) and examine signaling pathways (Hedgehog and Wnt) that may play a role in this process. Finally, we define a unique expression domain at the pylorus itself and detect novel pylorus-specific patterns for the transcription factor Gata3 and the secreted protein nephrocan. Developmental Dynamics 238:3205–3217, 2009. © 2009 Wiley-Liss, Inc. | en_US |
dc.format.extent | 787974 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley-Liss, Inc. | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cell & Developmental Biology | en_US |
dc.title | Dynamic patterning at the pylorus: Formation of an epithelial intestine–stomach boundary in late fetal life | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Pediatrics | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan ; Dr. Li and A.M. Udager contributed equally to this work. | en_US |
dc.contributor.affiliationum | Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan ; Department of Cell and Developmental Biology, University of Michigan Medical School, 2045 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI 48109-2200 | en_US |
dc.identifier.pmid | 19877272 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/64560/1/22134_ftp.pdf | |
dc.identifier.doi | 10.1002/dvdy.22134 | en_US |
dc.identifier.source | Developmental Dynamics | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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