Relative uptake of minoxidil into appendages and stratum corneum and permeation through human skin in vitro
dc.contributor.author | Grice, Jeffrey E. | en_US |
dc.contributor.author | Ciotti, Susan | en_US |
dc.contributor.author | Weiner, Norman D. | en_US |
dc.contributor.author | Lockwood, Peter | en_US |
dc.contributor.author | Cross, Sheree E. | en_US |
dc.contributor.author | Roberts, Michael S. | en_US |
dc.date.accessioned | 2010-01-05T15:12:12Z | |
dc.date.available | 2011-03-01T16:26:42Z | en_US |
dc.date.issued | 2010-02 | en_US |
dc.identifier.citation | Grice, Jeffrey E.; Ciotti, Susan; Weiner, Norman; Lockwood, Peter; Cross, Sheree E.; Roberts, Michael S. (2010). "Relative uptake of minoxidil into appendages and stratum corneum and permeation through human skin in vitro ." Journal of Pharmaceutical Sciences 99(2): 712-718. <http://hdl.handle.net/2027.42/64562> | en_US |
dc.identifier.issn | 0022-3549 | en_US |
dc.identifier.issn | 1520-6017 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/64562 | |
dc.description.abstract | We examined uptake of the model therapeutic agent, minoxidil, into appendages, stratum corneum (SC), and through human skin, under the influence of different vehicles. Quantitative estimation of therapeutic drug deposition into all three areas has not previously been reported. Finite doses of minoxidil (2%, w/v) in formulations containing varying amounts of ethanol, propylene glycol (PG), and water (60:20:20, 80:20:0, and 0:80:20 by volume, respectively) were used. Minoxidil in SC (by tape stripping), appendages (by cyanoacrylate casting), and receptor fluid was determined by liquid scintillation counting. At early times (30 min, 2 h), ethanol-containing formulations (60:20:20 and 80:20:0) caused significantly greater minoxidil retention in SC and appendages, compared to the formulation lacking ethanol (0:80:20). A significant increase in minoxidil receptor penetration occurred with the PG-rich 0:80:20 formulation after 12 h. We showed that deposition of minoxidil into appendages, SC, and skin penetration into receptor fluid were similar in magnitude. Transport by the appendageal route is likely to be a key determinant of hair growth promotion by minoxidil. © 2009 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 99:712–718, 2010 | en_US |
dc.format.extent | 120632 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Chemistry | en_US |
dc.subject.other | Food Science, Agricultural, Medicinal and Pharmaceutical Chemistry | en_US |
dc.title | Relative uptake of minoxidil into appendages and stratum corneum and permeation through human skin in vitro | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Pharmacy and Pharmacology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109 | en_US |
dc.contributor.affiliationother | Therapeutics Research Unit, School of Medicine, The University of Queensland, Princess Alexandra Hospital, Brisbane, Woolloongabba, Qld 4102, Australia | en_US |
dc.contributor.affiliationother | Formerly Pfizer Global Research and Development, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationother | Formerly Pfizer Global Research and Development, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationother | Therapeutics Research Unit, School of Medicine, The University of Queensland, Princess Alexandra Hospital, Brisbane, Woolloongabba, Qld 4102, Australia | en_US |
dc.contributor.affiliationother | Therapeutics Research Unit, School of Medicine, The University of Queensland, Princess Alexandra Hospital, Brisbane, Woolloongabba, Qld 4102, Australia ; Therapeutics Research Unit, School of Medicine, The University of Queensland, Princess Alexandra Hospital, Brisbane, Woolloongabba, Qld 4102, Australia. Telephone: +61-7-3240-5803; Fax: +61-7-3240-5806. | en_US |
dc.identifier.pmid | 19544367 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/64562/1/21856_ftp.pdf | |
dc.identifier.doi | 10.1002/jps.21856 | en_US |
dc.identifier.source | Journal of Pharmaceutical Sciences | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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