Variants of the serotonin transporter gene and NEO-PI-R Neuroticism: No association in the BLSA and SardiNIA samples
dc.contributor.author | Terracciano, Antonio | en_US |
dc.contributor.author | Balaci, Lenuta | en_US |
dc.contributor.author | Thayer, Jason | en_US |
dc.contributor.author | Scally, Matthew | en_US |
dc.contributor.author | Kokinos, Sarah | en_US |
dc.contributor.author | Ferrucci, Luigi | en_US |
dc.contributor.author | Tanaka, Toshiko | en_US |
dc.contributor.author | Zonderman, Alan B. | en_US |
dc.contributor.author | Sanna, Serena | en_US |
dc.contributor.author | Olla, Nazario | en_US |
dc.contributor.author | Zuncheddu, Maria Antonietta | en_US |
dc.contributor.author | Naitza, Silvia | en_US |
dc.contributor.author | Busonero, Fabio | en_US |
dc.contributor.author | Uda, Manuela | en_US |
dc.contributor.author | Schlessinger, David | en_US |
dc.contributor.author | Abecasis, Gonçalo R. | en_US |
dc.contributor.author | Costa, Paul T. | en_US |
dc.date.accessioned | 2010-01-05T15:13:06Z | |
dc.date.available | 2010-03-01T21:10:29Z | en_US |
dc.date.issued | 2009-12-05 | en_US |
dc.identifier.citation | Terracciano, Antonio; Balaci, Lenuta; Thayer, Jason; Scally, Matthew; Kokinos, Sarah; Ferrucci, Luigi; Tanaka, Toshiko; Zonderman, Alan B.; Sanna, Serena; Olla, Nazario; Zuncheddu, Maria Antonietta; Naitza, Silvia; Busonero, Fabio; Uda, Manuela; Schlessinger, David; Abecasis, GonÇalo R.; Costa, Paul T. (2009). "Variants of the serotonin transporter gene and NEO-PI-R Neuroticism: No association in the BLSA and SardiNIA samples How to Cite this Article: Terracciano A, Balaci L, Thayer J, Scally M, Kokinos S, Ferrucci L, Tanaka T, Zonderman AB, Sanna S, Olla N, Zuncheddu MA, Naitza S, Busonero F, Uda M, Schlessinger D, Abecasis GR, Costa PT Jr. 2009. Variants of the Serotonin Transporter Gene and NEO-PI-R Neuroticism: No Association in the BLSA and SardiNIA Samples. Am J Med Genet Part B 150B:1070–1077. Paul T. Costa Jr receives royalties from the Revised NEO Personality Inventory. The authors declare that they have no other competing interests. ." American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 150B(8): 1070-1077. <http://hdl.handle.net/2027.42/64573> | en_US |
dc.identifier.issn | 1552-4841 | en_US |
dc.identifier.issn | 1552-485X | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/64573 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=19199283&dopt=citation | en_US |
dc.description.abstract | The polymorphism in the serotonin transporter gene promoter region (5-HTTLPR) is by far the most studied variant hypothesized to influence Neuroticism-related personality traits. The results of previous studies have been mixed and appear moderated by the personality questionnaire used. Studies that used the TCI to assess Harm Avoidance or the EPQ to assess Neuroticism have found no association with the 5-HTTLPR. However, studies that used the NEO-PI-R or related instruments (NEO-PI, NEO-FFI) to measure Neuroticism have found some evidence of association. This study examines the association of variants in the serotonin transporter gene in a sample from a genetically isolated population within Sardinia (Italy) that is several times larger than previous samples that used the NEO-PI-R (N = 3,913). The association was also tested in a sample (N = 548) from the Baltimore Longitudinal Study of Aging (BLSA), in which repeated NEO-PI-R assessments were obtained. In the SardiNIA sample, we found no significant association of the 5-HTTLPR genotypes with Neuroticism or its facets (Anxiety, Angry-Hostility, Depression, Self-Consciousness, Impulsiveness, and Vulnerability). In the BLSA sample, we found lower scores on Neuroticism traits for the heterozygous group, which is inconsistent with previous studies. We also examined eight SNPs in the SardiNIA (N = 3,972) and nine SNPs in the BLSA (N = 1,182) that map within or near the serotonin transporter gene (SLC6A4), and found no association. Along with other large studies that used different phenotypic measures and found no association, this study substantially increases the evidence against a link between 5-HTT variants and Neuroticism-related traits. © 2009 Wiley-Liss, Inc. | en_US |
dc.format.extent | 209646 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Genetics | en_US |
dc.title | Variants of the serotonin transporter gene and NEO-PI-R Neuroticism: No association in the BLSA and SardiNIA samples | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Medicine (General) | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationother | National Institute on Aging, NIH, DHHS, Baltimore, Maryland ; National Institute on Aging, NIH, DHHS, 251 Bayview Blvd, Baltimore, MD 21224. | en_US |
dc.contributor.affiliationother | Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Cagliari, Italy | en_US |
dc.contributor.affiliationother | National Institute on Aging, NIH, DHHS, Baltimore, Maryland | en_US |
dc.contributor.affiliationother | National Institute on Aging, NIH, DHHS, Baltimore, Maryland | en_US |
dc.contributor.affiliationother | National Institute on Aging, NIH, DHHS, Baltimore, Maryland | en_US |
dc.contributor.affiliationother | National Institute on Aging, NIH, DHHS, Baltimore, Maryland | en_US |
dc.contributor.affiliationother | Medstar Research Institute, Baltimore, Maryland | en_US |
dc.contributor.affiliationother | National Institute on Aging, NIH, DHHS, Baltimore, Maryland | en_US |
dc.contributor.affiliationother | Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Cagliari, Italy | en_US |
dc.contributor.affiliationother | Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Cagliari, Italy | en_US |
dc.contributor.affiliationother | Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Cagliari, Italy | en_US |
dc.contributor.affiliationother | Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Cagliari, Italy | en_US |
dc.contributor.affiliationother | Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Cagliari, Italy | en_US |
dc.contributor.affiliationother | Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Cagliari, Italy | en_US |
dc.contributor.affiliationother | National Institute on Aging, NIH, DHHS, Baltimore, Maryland | en_US |
dc.contributor.affiliationother | National Institute on Aging, NIH, DHHS, Baltimore, Maryland | en_US |
dc.identifier.pmid | 19199283 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/64573/1/30932_ftp.pdf | |
dc.identifier.doi | 10.1002/ajmg.b.30932 | en_US |
dc.identifier.source | American Journal of Medical Genetics Part B: Neuropsychiatric Genetics | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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