Multifunctional Magnetoplasmonic Nanoparticle Assemblies for Cancer Therapy and Diagnostics (Theranostics)
dc.contributor.author | Chen, Wei | en_US |
dc.contributor.author | Xu, Naifeng | en_US |
dc.contributor.author | Xu, Liguang | en_US |
dc.contributor.author | Wang, Libing | en_US |
dc.contributor.author | Li, Zuokun | en_US |
dc.contributor.author | Ma, Wei | en_US |
dc.contributor.author | Zhu, Yingyue | en_US |
dc.contributor.author | Xu, Chuanlai | en_US |
dc.contributor.author | Kotov, Nicholas A. | en_US |
dc.date.accessioned | 2010-02-02T15:32:06Z | |
dc.date.available | 2011-03-01T16:26:45Z | en_US |
dc.date.issued | 2010-01-18 | en_US |
dc.identifier.citation | Chen, Wei; Xu, Naifeng; Xu, Liguang; Wang, Libing; Li, Zuokun; Ma, Wei; Zhu, Yingyue; Xu, Chuanlai; Kotov, Nicholas A. (2010). "Multifunctional Magnetoplasmonic Nanoparticle Assemblies for Cancer Therapy and Diagnostics (Theranostics)." Macromolecular Rapid Communications 31(2): 228-236. <http://hdl.handle.net/2027.42/64924> | en_US |
dc.identifier.issn | 1022-1336 | en_US |
dc.identifier.issn | 1521-3927 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/64924 | |
dc.description.abstract | In this work, we describe the preparation and biomedical functionalities of complex nanoparticle assemblies with magnetoplasmonic properties suitable for simultaneous cancer therapy and diagnostics (theranostics). Most commonly magnetoplasmonic nanostructures are made by careful adaptation of metal reduction protocols which is both tedious and restrictive. Here we apply the strategy of nanoscale assemblies to prepare such systems from individual building blocks. The prepared superstructures are based on magnetic Fe 3 O 4 nanoparticles encapsulated in silica shell representing the magnetic module. The cores are surrounded in a corona-like fashion by gold nanoparticles representing the plasmonic module. As additional functionality they were also coated by poly(ethyleneglycol) chains as a cloaking agent to extend the blood circulation time. The preparation is exceptionally simple and allows one to vary the contribution of each function. Both modules can carry drugs and, in this study, they were loaded with the potential anticancer drug curcumin. A comprehensive set of microscopy, spectroscopy and biochemical methods were applied to characterize both imaging and therapeutic function of the nanoparticle assemblies against leukemia HL-60 cells. High contrast magnetic resonance images and high apoptosis rates demonstrate the success of assembly approach for the preparation of magnetoplasmonic nanoparticles. This technology allows one to easily “dial in” the functionalities in the clinical setting for personalized theranostic regiments. | en_US |
dc.format.extent | 73207 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | WILEY-VCH Verlag | en_US |
dc.subject.other | Chemistry | en_US |
dc.subject.other | Polymer and Materials Science | en_US |
dc.title | Multifunctional Magnetoplasmonic Nanoparticle Assemblies for Cancer Therapy and Diagnostics (Theranostics) | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbsecondlevel | Chemical Engineering | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Materials Science and Engineering | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Chemical Engineering, University of Michigan, Ann Arbor, 48109 Michigan, USA ; School of Food Science and Technology, Jiangnan University, Wuxi 214122, Jiangsu Province, China | en_US |
dc.contributor.affiliationum | Department of Chemical Engineering, University of Michigan, Ann Arbor, 48109 Michigan, USA ; Department of Chemical Engineering, University of Michigan, Ann Arbor, 48109 Michigan, USA. | en_US |
dc.contributor.affiliationother | School of Food Science and Technology, Jiangnan University, Wuxi 214122, Jiangsu Province, China | en_US |
dc.contributor.affiliationother | School of Food Science and Technology, Jiangnan University, Wuxi 214122, Jiangsu Province, China | en_US |
dc.contributor.affiliationother | School of Food Science and Technology, Jiangnan University, Wuxi 214122, Jiangsu Province, China | en_US |
dc.contributor.affiliationother | School of Food Science and Technology, Jiangnan University, Wuxi 214122, Jiangsu Province, China | en_US |
dc.contributor.affiliationother | School of Food Science and Technology, Jiangnan University, Wuxi 214122, Jiangsu Province, China | en_US |
dc.contributor.affiliationother | School of Food Science and Technology, Jiangnan University, Wuxi 214122, Jiangsu Province, China | en_US |
dc.contributor.affiliationother | School of Food Science and Technology, Jiangnan University, Wuxi 214122, Jiangsu Province, China ; School of Food Science and Technology, Jiangnan University, Wuxi 214122, Jiangsu Province, China. | en_US |
dc.identifier.pmid | 21590896 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/64924/1/marc_200900793_sm_supplfigs.pdf | |
dc.identifier.doi | 10.1002/marc.200900793 | en_US |
dc.identifier.source | Macromolecular Rapid Communications | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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