Intravoxel water diffusion heterogeneity imaging of human high-grade gliomas
dc.contributor.author | Kwee, Thomas C. | en_US |
dc.contributor.author | Galbán, Craig J. | en_US |
dc.contributor.author | Tsien, Christina I. | en_US |
dc.contributor.author | Junck, Larry | en_US |
dc.contributor.author | Sundgren, Pia C. | en_US |
dc.contributor.author | Ivancevic, Marko K. | en_US |
dc.contributor.author | Johnson, Timothy D. | en_US |
dc.contributor.author | Meyer, Charles R. | en_US |
dc.contributor.author | Rehemtulla, Alnawaz | en_US |
dc.contributor.author | Ross, Brian D. | en_US |
dc.contributor.author | Chenevert, Thomas L. | en_US |
dc.date.accessioned | 2010-03-01T20:22:09Z | |
dc.date.available | 2011-02-01T20:36:36Z | en_US |
dc.date.issued | 2010-02 | en_US |
dc.identifier.citation | Kwee, Thomas C.; GalbÁn, Craig J.; Tsien, Christina; Junck, Larry; Sundgren, Pia C.; Ivancevic, Marko K.; Johnson, Timothy D.; Meyer, Charles R.; Rehemtulla, Alnawaz; Ross, Brian D.; Chenevert, Thomas L. (2010). "Intravoxel water diffusion heterogeneity imaging of human high-grade gliomas." NMR in Biomedicine 23(2): 179-187. <http://hdl.handle.net/2027.42/65045> | en_US |
dc.identifier.issn | 0952-3480 | en_US |
dc.identifier.issn | 1099-1492 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/65045 | |
dc.description.abstract | This study aimed to determine the potential value of intravoxel water diffusion heterogeneity imaging for brain tumor characterization and evaluation of high-grade gliomas, by comparing an established heterogeneity index ( Α value) measured in human high-grade gliomas to those of normal appearing white and grey matter landmarks. Twenty patients with high-grade gliomas prospectively underwent diffusion-weighted magnetic resonance imaging using multiple b-values. The stretched-exponential model was used to generate Α and distributed diffusion coefficient (DDC) maps. The Α values and DDCs of the tumor and contralateral anatomic landmarks were measured in each patient. Differences between Α values of tumors and landmark tissues were assessed using paired t- tests. Correlation between tumor Α and tumor DDC was assessed using Pearson's correlation coefficient. Mean Α of tumors was significantly lower than that of contralateral frontal white matter ( p = 0.0249), basal ganglia ( p < 0.0001), cortical grey matter ( p < 0.0001), and centrum semiovale ( p = 0.0497). Correlation between tumor Α and tumor DDC was strongly negative (Pearson correlation coefficient, −0.8493; p < 0.0001). The heterogeneity index Α of human high-grade gliomas is significantly different from those of normal brain structures, which potentially offers a new method for evaluating brain tumors. The observed negative correlation between tumor Α and tumor DDC requires further investigation. Copyright © 2009 John Wiley & Sons, Ltd. | en_US |
dc.format.extent | 665083 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | John Wiley & Sons, Ltd. | en_US |
dc.subject.other | Chemistry | en_US |
dc.subject.other | Analytical Chemistry and Spectroscopy | en_US |
dc.title | Intravoxel water diffusion heterogeneity imaging of human high-grade gliomas | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Electrical Engineering | en_US |
dc.subject.hlbsecondlevel | Physics | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Radiology, University of Michigan Medical Center, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Center for Molecular Imaging, University of Michigan Medical Center, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Department of Neurology, University of Michigan Medical Center, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Department of Radiology, University of Michigan Medical Center, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Department of Radiology, University of Michigan Medical Center, Ann Arbor, MI, USA ; Philips Healthcare, MR Clinical Science, Cleveland, OH, USA | en_US |
dc.contributor.affiliationum | Department of Biostatistics, University of Michigan Medical Center, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Center for Molecular Imaging, University of Michigan Medical Center, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Center for Molecular Imaging, University of Michigan Medical Center, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Center for Molecular Imaging, University of Michigan Medical Center, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Department of Radiology, University of Michigan Medical Center, Ann Arbor, MI, USA ; Department of Radiology, University of Michigan Medical Center, B2A209 UH 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA. | en_US |
dc.identifier.pmid | 19777501 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/65045/1/1441_ftp.pdf | |
dc.identifier.doi | 10.1002/nbm.1441 | en_US |
dc.identifier.source | NMR in Biomedicine | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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