Show simple item record

Gastrointestinal-projecting neurones in the dorsal motor nucleus of the vagus exhibit direct and viscerotopically organized sensitivity to orexin

dc.contributor.authorGrabauskas, Gintautasen_US
dc.contributor.authorMoises, Hylan C.en_US
dc.date.accessioned2010-04-01T14:41:33Z
dc.date.available2010-04-01T14:41:33Z
dc.date.issued2003-05en_US
dc.identifier.citationGrabauskas, Gintautas; Moises, Hylan C. (2003). "Gastrointestinal-projecting neurones in the dorsal motor nucleus of the vagus exhibit direct and viscerotopically organized sensitivity to orexin." The Journal of Physiology 549(1): 37-56. <http://hdl.handle.net/2027.42/65136>en_US
dc.identifier.issn0022-3751en_US
dc.identifier.issn1469-7793en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/65136
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=12679367&dopt=citationen_US
dc.format.extent1059238 bytes
dc.format.extent3110 bytes
dc.format.mimetypeapplication/octet-stream
dc.format.mimetypetext/plain
dc.publisherBlackwell Publishing Ltden_US
dc.rightsThe Physiological Society 2003en_US
dc.titleGastrointestinal-projecting neurones in the dorsal motor nucleus of the vagus exhibit direct and viscerotopically organized sensitivity to orexinen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPhysiologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Physiology and Neuroscience Program, University of Michigan Medical School, Ann Arbor, MI 48109-0622, USAen_US
dc.identifier.pmid12679367en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/65136/1/jphysiol.2002.029546.pdf
dc.identifier.doi10.1113/jphysiol.2002.029546en_US
dc.identifier.sourceThe Journal of Physiologyen_US
dc.identifier.citedreferenceBernardis LL & Bellinger LL ( 1996 ). The lateral hypothalamic area revisited: ingestive behavior. Neurosci Biobehav Rev 20, 189 – 287.en_US
dc.identifier.citedreferenceBerthoud HR, Carlson NR & Powley TL ( 1991 ). Topography of efferent vagal innervation of the rat gastrointestinal tract. Am J Physiol 260, R200 – 207.en_US
dc.identifier.citedreferenceBerthoud HR, Jedrzejewska A & Powley TL ( 1990 ). Simultaneous labeling of vagal innervation of the gut and afferent projections from the visceral forebrain with DiI injected into the dorsal vagal complex in the rat. J Comp Neurol 301, 65 – 79.en_US
dc.identifier.citedreferenceBertolino M, Vicini S, Gillis R & Travagli RA ( 1997 ). Presynaptic Α2-adrenoceptors inhibit excitatory synaptic transmission in rat brain stem. Am J Physiol 272, G654 – 661.en_US
dc.identifier.citedreferenceBrown RE, Sergeeva O, Eriksson KS & Hass HL ( 2001 ). Orexin A excites serotonergic neurons in the dorsal raphe nucleus of the rat. Neuropharmacol 40, 457 – 459.en_US
dc.identifier.citedreferenceBrowning KN, Kalyuzhny AE & Travagli RA ( 2002 ). Opioid peptides inhibit excitatory but not inhibitory synaptic transmission in the rat dorsal motor nucleus of the vagus. J Neurosci 22, 2998 – 3004.en_US
dc.identifier.citedreferenceBrowning KN, Renehan WE & Travagli RA ( 1999 ). Electrophysiological and morphological heterogeneity of rat dorsal vagal neurones which project to specific areas of the gastrointestinal tract. J Physiol 517, 521 – 532.en_US
dc.identifier.citedreferenceBrowning KN & Travagli RA ( 1999 ). Characterization of the in vitro effects of 5-hydroxytryptamine (5-HT) on identified neurones of the rat dorsal motor nucleus of the vagus (DMV). Br J Pharmacol 128, 1307 – 1315.en_US
dc.identifier.citedreferenceCai XJ, Evans ML, Lister CA, Leslie RA, Arch JjS, Wilson S & Williams G ( 2001 ). Hypoglycemia activates orexin neurons and selectively increases hypothalamic orexin-B levels: responses inhibited by feeding and possibly mediated by the nucleus of the solitary tract. Diabetes 50, 105 – 112.en_US
dc.identifier.citedreferenceCai XJ, Widdowson PS, Harrold J, Wilson S, Buckingham RE, Jonathan RS, Tadayyon M, Clapham JC, Wilding J & Williams G ( 1999 ). Hypothalamic orexin expression: modulation by blood glucose and feeding. Diabetes 48, 2132 – 2137.en_US
dc.identifier.citedreferenceDate Y, Ueta Y, Yamashita H, Yamaguchi H, Matsukura S, Kangawa K, Sakurai T, Yanagisawa M & Nakazato, M. ( 1999 ). Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems. Proc Natl Acad Sci U S A 96, 748 – 753.en_US
dc.identifier.citedreferenceDe Lecea L, Kilduff TS, Peyron C, Gao X-B, Foye PE, Danielson PE, Fukuhara C, Battenberg ElF, Gautvik VT, Bartlett FS II, Frankel WN, van den Pol AN, Bloom FE, Gautvik KM & Sutcliffe JG ( 1998 ). The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity. Proc Natl Acad Sci U S A 95, 322 – 327.en_US
dc.identifier.citedreferenceDube MG, Kalra SP & Kalra PS ( 1999 ). Food intake elicited by central administration of orexins/hypocretins: identification of hypothalamic sites of action. Brain Res 842, 473 – 477.en_US
dc.identifier.citedreferenceDubois-Dauphin M, Raggenbass H, Widmer H, Tribollet E & Dreifuss JJ ( 1992 ). Morphological and electrophysiological evidence for postsynaptic localization of functional oxytocin receptors in the rat dorsal motor nucleus of the vagus nerve. Brain Res 575, 124 – 131.en_US
dc.identifier.citedreferenceEriksson KS, Sergeeva O, Brown RE & Haas HL ( 2001 ). Orexin/hypocretin excites the histaminergic neurons of the tuberomammillary nucleus. J Neurosci 21, 9273 – 9279.en_US
dc.identifier.citedreferenceFlanagan LM, Olson BR, Sved AF, Verbalis JG & Stricker EM ( 1992 ). Gastric motility in conscious rats given oxytocin and an oxytocin antagonist centrally. Brain Res 578, 256 – 260.en_US
dc.identifier.citedreferenceGillis RA, Quest JA, Pagan FD & Norman WP ( 1989 ). Control centers in the central nervous system for regulating gastrointestinal motility. In Handbook of Physiology, section 6, The Gastrointestinal System, vol. 1, Motility and Circulation, ed. Wood JD, part 1, pp. 621 – 683. American Physiological Society, Bethesda, MD, USA.en_US
dc.identifier.citedreferenceGrabauskas G & Moises HC ( 2001 ). Neurons in dorsal motor nucleus of the vagus (DMV) exhibit viscerotopically organized sensitivity to hypocretins. Soc Neurosci Abstr 27, 839.en_US
dc.identifier.citedreferenceGrudt TJ, van den Pol AN & Perl ER ( 2002 ). Hypocretin-2 (orexin-B) modulation of superficial dorsal horn activity in rat. J Physiol 538, 517 – 525.en_US
dc.identifier.citedreferenceHarrison TA, Chen C–T, Dun NJ & Chang J–K ( 1999 ). Hypothalamic orexin A-immunoreactive neurons project to the rat dorsal medulla. Neurosci Lett 273, 17 – 20.en_US
dc.identifier.citedreferenceHorvath TL, Diano S & van den Pol AN ( 1999 a ). Synaptic interaction between hypocretin (orexin) and neuropeptide Y cells in the rodent and primate hypothalamus: a novel circuit implicated in metabolic and endocrine regulations. J Neurosci 19, 1072 – 1087.en_US
dc.identifier.citedreferenceHorvath TL, Peyron C, Diano S, Ivanov A, Aston-Jones G, Kilduff TS & van den Pol AN ( 1999 b ). Hypocretin (orexin) activation and synaptic innervation of the locus coeruleus noradrenergic system. J Comp Neurol 415, 145 – 159.en_US
dc.identifier.citedreferenceHwang L-L, Chen C–T & Dun NJ ( 2001 ). Mechanisms of orexin-induced depolarizations in rat dorsal motor nucleus of vagus neurones in vitro. J Physiol 537, 511 – 520.en_US
dc.identifier.citedreferenceIvanov A & Aston-Jones G ( 2000 ). Hypocretin/orexin depolarizes and decreases potassium conductance in locus coeruleus neurons. Neuroreport 11, 1755 – 1758.en_US
dc.identifier.citedreferenceKirchgessner AL & Liu M ( 1999 ). Orexin synthesis and response in the gut. Neuron 24, 941 – 951.en_US
dc.identifier.citedreferenceKrowicki ZK, Burmeister MA, Berthoud H–R, Scullion RT, Fuchs K & Hornby PJ ( 2002 ). Orexins in rat dorsal motor nucleus of the vagus potently stimulate gastric motor function. Am J Physiol 283, 1 – 15.en_US
dc.identifier.citedreferenceKrowicki ZK & Hornby PJ ( 1995 ). Hindbrain neuroactive substances controlling gastrointestinal function. In Regulatory Mechanism in Gastrointestinal Function, ed. Gaginella TS, pp. 277 – 319. CRC Press, Boca Raton, FL, USA.en_US
dc.identifier.citedreferenceLiu R-J, van den Pol AN & Aghajanian GK ( 2002 ). Hypocretins (orexins) regulate serotonin neurons in the dorsal raphe nucleus by excitatory direct and inhibitory indirect actions. J Neurosci 22, 9453 – 9464.en_US
dc.identifier.citedreferenceLoewy AD, ( 1990 ). Central autonomic pathways. In Central Regulation of Autonomic Functions, ed. Loewy AD & Spyer KM, pp. 88 – 103. Oxford University Press, New York.en_US
dc.identifier.citedreferenceMarcus JN, Aschkenasi CJ, Lee CE, Chemelli RM, Saper CB, Yanagisawa M & Elmquist JK ( 2001 ). Differential expression of orexin receptors 1 and 2 in the rat brain. J Comp Neurol 435, 6 – 25.en_US
dc.identifier.citedreferenceMcCann MJ & Rogers RC ( 1990 ). Oxytocin excites gastric-related neurones in rat dorsal vagal complex. J Physiol 428, 95 – 108.en_US
dc.identifier.citedreferenceNaslund E, Ehrstrom M, Hellstrom PM & Kirchgessner AL ( 2002 ). Localization and effects of orexin on fasting motility in the rat duodenum. Am J Phsyiol 282, G470 – 479.en_US
dc.identifier.citedreferencePeyron C, Tighe DK, van den Pol AN, DeLecea L, Heller HC, Sutcliffe JG & Kilduff TS ( 1998 ). Neurons containing hypocretin (orexin) project to multiple neuronal systems. J Neurosci 18, 9996 – 10015.en_US
dc.identifier.citedreferencePowley TL, ( 2000 ). Nutritional implications of cephalic phase responses: Vagal circuitry mediating cephalic-phase responses to food. Appetite 34, 184 – 188.en_US
dc.identifier.citedreferencePowley TL, Berthoud H-R, Fox EA & Laughton W ( 1992 ). The dorsal vagal complex forms a sensory-motor lattice: The circuitry of gastrointestinal reflexes. In Neuroanatomy and Physiology of Abdominal Vagal Afferents, ed. Ritter, RC & Barnes CD, pp. 57 – 79. CRC Press, Boca Raton, FL, USA.en_US
dc.identifier.citedreferencePowley TL, Fox EA & Berthoud H-R ( 1987 ). Retrograde tracer technique for assessment of selective and total subdiaphragmatic vagotomies. AmJ Phsyiol 253, R361 – 370.en_US
dc.identifier.citedreferenceRaggenbass M & Dreifuss JJ ( 1992 ). Mechanism of action of oxytocin in rat vagal neurones: induction of a sustained sodium-dependent current. J Physiol 457, 131 – 142.en_US
dc.identifier.citedreferenceRinaman L, ( 1998 ). Oxytocinergic inputs to the nucleus of the solitary tract and dorsal motor nucleus of the vagus in neonatal rats. J Comp Neurol 399, 101 – 109.en_US
dc.identifier.citedreferenceRogers RC & Hermann GE ( 1985 ). Dorsal medullary oxytocin, vasopressin, oxytocin antagonist, and TRH effects on gastric acid secretion and heart rate. Peptides 6, 1143 – 1148.en_US
dc.identifier.citedreferenceRogers RC & Hermann GE ( 1987 ). Oxytocin, oxytocin antagonist, TRH, and hypothalamic paraventricular nucleus stimulation effects on gasric motility. Peptides 8, 505 – 513.en_US
dc.identifier.citedreferenceRossiter CD, Norman WP, Jain M, Hornby PJ, Benjamin S & Gillis RA ( 1990 ). Control of lower esophageal sphincter pressure by two sites in dorsal motor nucleus of the vagus. Am J Physiol 259, G899 – 906.en_US
dc.identifier.citedreferenceSakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richardson JA, Kozlowski GP, Wilson S, Arch JRS, Buckingham RE, Haynes AC, Carr SA, Annan RS, McNulty DE, Liu W-S, Terrett JA, Elshourbagy NA, Bergsma DJ & Yanagisawa M ( 1998 ). Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92, 573 – 585.en_US
dc.identifier.citedreferenceShapiro R & Miselis RR ( 1985 ). The central organization of the vagus nerve innervating the stomach of the rat. J Comp Neurol 238, 473 – 488.en_US
dc.identifier.citedreferenceSmart D, Jerman JC, Brough SJ, Rushton SL, Murdock PR, Jewitt F, Elshourbagy NA, Ellis CE, Middlemiss DN & Brown F ( 1999 ). Characterization of recombinant human orexin receptor pharmacology in a chinese hamster ovary cell-line using FLIPR. Br J Pharmacol 128, 1 – 3.en_US
dc.identifier.citedreferenceSmith BN, Davis SF, van den Pol AN & Xu W ( 2002 ). Selective enhancement of excitatory synaptic activity in the rat nucleus tractus solitarius by hypocretin 2. Neuroscience 115, 707 – 714.en_US
dc.identifier.citedreferenceSutcliffe JG & de Lecea L. ( 2002 ). The hypocretins:setting the arousal threshold. Nature Neurosci 3, 339 – 349.en_US
dc.identifier.citedreferenceSwanson LW & Kuypers HGJM ( 1980 ). The paraventricular nucleus of the hypothalamus: cytoarchitectonic subdivision and organization of projections to the pituitary, dorsal vagal complex, and spinal cord as demonstrated by retrograde fluorescence double-labeling methods. J Comp Neurol 194, 555 – 570.en_US
dc.identifier.citedreferenceTakahashi N, Okumura T, Yamada H & Kohgo Y ( 1999 ). Stimulation of gastric acid secretion by centrally administered orexin-A in conscious rats. Biochem Biophys Res Comm 254, 623 – 627.en_US
dc.identifier.citedreferenceTakahashi T & Owyang C ( 1997 ). Characterization of vagal pathways mediating gastric accomodation reflex in rats. J Physiol 504, 479 – 488.en_US
dc.identifier.citedreferenceTravagli RA, Gillis RA, Rossiter CD & Vicini S ( 1991 ). Glutamate and GABA-mediated synaptic currents in neurons of the rat dorsal motor nucleus of the vagus. Am J Physiol 260, G531 – 536.en_US
dc.identifier.citedreferenceTravagli RA & Williams JT ( 1996 ). Endrogenous monoamines inhibit glutamate transmission in the spinal trigeminal nucleus of the guinea-pig. J Physiol 491, 177 – 185.en_US
dc.identifier.citedreferenceTrombley PQ & Westbrook GL ( 1992 ). Excitatory synaptic transmission in cultures of rat olfactory bulb. J Neurophysiol 64, 598 – 606.en_US
dc.identifier.citedreferencevan den Pol AN, Gao X-B, Obrietan K, Kildruff TS & Belousov AB ( 1998 ). Presynaptic and postsynaptic actions and modulation of neuroendocrine neurons by a new hypothalamic peptide, hypocretin/orexin. J Neurosci 18, 7962 – 7971.en_US
dc.identifier.citedreferenceWillie JT, Chemelli RM, Sinton CM & Yanagisawa M. ( 2001 ). To eat or to sleep? Orexin in the regulation of feeding and wakefulness. Annu Rev Neurosci 24, 429 – 458.en_US
dc.identifier.citedreferenceWillis A, Mihalevich M, Neff RA & Mendelowitz D ( 1996 ). Three types of postsynaptic glutamatergic receptors are activated in DMNX neurons upon stimulation of NTS. Am J Physiol 271, R1614 – 1619.en_US
dc.identifier.citedreferenceYamada H, Okumura T, Motomura W, Kobayashi Y & Kohgo Y ( 2000 ). Inhibition of food intake by central injection of anti-orexin antibody in fasted rats. Biochem Biophys Res Commun 267, 527 – 531.en_US
dc.identifier.citedreferenceYamamoto Y, Ueta Y, Date Y, Nakazato M, Hara Y, Serino R, Nomura M, Shibuya I, Matsukura S & Yamashita H ( 1999 ). Down regulation of the prepro-orexin gene expression in genetically obese mice. Mol Brain Res 65, 14 – 22.en_US
dc.identifier.citedreferenceZheng ZL, Rogers RC & Travagli RA ( 1999 ). Selective gastric projections of nitric oxide synthase-containing vagal brainstem neurons. Neuroscience 90, 685 – 694.en_US
dc.identifier.citedreferenceZhou S, Tian D, Owyang C & Moises HC ( 2001 ). Hypocretins modulate calcium channel currents in neurones of dorsal motor nucleus of vagus (DMV). Soc Neurosci Abstr 24, 503.en_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


Files in this item

Show simple item record

Remediation of Harmful Language

The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.

Accessibility

If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.